Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models - Wikidata - wikimedia - TriplyDB

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

http://www.wikidata.org/entity/Q36434528

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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function Inside out: the role of nucleocytoplasmic transport in ALS and FTLD Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders Emerging Functions of Circular RNAs Engineering enhanced protein disaggregases for neurodegenerative disease CircRNA: functions and properties of a novel potential biomarker for cancer.Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.Lariat intronic RNAs in the cytoplasm of Xenopus tropicalis oocytes Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1.Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.Yeast Phenomics: An Experimental Approach for Modeling Gene Interaction Networks that Buffer Disease.Coupling and coordination in gene expression processes with pre-mRNA splicing.Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.The Spectrum of C9orf72-mediated Neurodegeneration and Amyotrophic Lateral Sclerosis.PABPN1 suppresses TDP-43 toxicity in ALS disease models.Intron Lariat RNA Inhibits MicroRNA Biogenesis by Sequestering the Dicing Complex in Arabidopsis High-throughput transformation of Saccharomyces cerevisiae using liquid handling robots Design, Synthesis, and Properties of Phosphoramidate 2',5'-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme Stress granules as crucibles of ALS pathogenesis.Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases.Motor neuron disease in 2012: Novel causal genes and disease modifiers.Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.Protein aggregation in amyotrophic lateral sclerosis.Lives that introns lead after splicing.Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective.Yeast genetic screen reveals novel therapeutic strategy for ALS.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.FTD and ALS--translating mouse studies into clinical trials.Circular RNAs: a new frontier in the study of human diseases.Regulatory Role of Circular RNAs and Neurological Disorders.Circular RNAs: the Emerging Class of Non-coding RNAs and Their Potential Role in Human Neurodegenerative Diseases.Exploring the power of yeast to model aging and age-related neurodegenerative disorders.ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration.TDP-43 toxicity and the usefulness of junk An amyotrophic lateral sclerosis-linked mutation in GLE1 alters the cellular pool of human Gle1 functional isoforms.

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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

http://www.wikidata.org/entity/Q36434528

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Inhibition of RNA lariat debra ...... toxicity in ALS disease models

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Inhibition of RNA lariat debra ...... toxicity in ALS disease models

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Inhibition of RNA lariat debra ...... toxicity in ALS disease models

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Inhibition of RNA lariat debra ...... toxicity in ALS disease models

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Inhibition of RNA lariat debra ...... toxicity in ALS disease models

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Inhibition of RNA lariat debra ...... toxicity in ALS disease models

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Nature Genetics

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Inhibition of RNA lariat debra ...... toxicity in ALS disease models

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Aaron D Gitler

http://www.w3.org/2001/XMLSchema#string

Emily A Scarborough

http://www.w3.org/2001/XMLSchema#string

Maria Armakola

http://www.w3.org/2001/XMLSchema#string

Matthew J Higgins

http://www.w3.org/2001/XMLSchema#string

Nevan J Krogan

http://www.w3.org/2001/XMLSchema#string

Robert V Farese

http://www.w3.org/2001/XMLSchema#string

Sami J Barmada

http://www.w3.org/2001/XMLSchema#string

Steven Finkbeiner

http://www.w3.org/2001/XMLSchema#string

Xiaodong Fang

http://www.w3.org/2001/XMLSchema#string

Zamia Diaz

http://www.w3.org/2001/XMLSchema#string

P2860

DBR1 siRNA inhibition of HIV-1 replication.

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase.

TDP-43-mediated neuron loss in vivo requires RNA-binding activity

Isolation and characterization of the gene encoding yeast debranching enzyme.

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

Global mapping of the yeast genetic interaction network.

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1302-1309

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scholarly article

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10.1038/NG.2434

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12

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44

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Matthew D Figley

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2012-10-28T00:00:00Z

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232720493

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23104007

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amyotrophic lateral sclerosis

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3510335

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