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Progressive ataxia due to a missense mutation in a calcium-channel geneThe crystal structure of a voltage-gated sodium channelNew regulators of a high affinity Ca2+ influx system revealed through a genome-wide screen in yeastDe novo mutation in CACNA1A caused acetazolamide-responsive episodic ataxiaMechanisms of permeation and selectivity in calcium channelsTwo sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protonsGenetically engineered metal ion binding sites on the outside of a Channel's transmembrane beta-barrel.Ion conduction and conformational flexibility of a bacterial voltage-gated sodium channel.Molecular determinants of a Ca2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity of intrapore glutamates.Molecular motions within the pore of voltage-dependent sodium channelsSide-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel.Barium plateau potentials of CA1 pyramidal neurons elicit all-or-none extracellular alkaline shifts via the plasma membrane calcium ATPaseIon permeation and glutamate residues linked by Poisson-Nernst-Planck theory in L-type calcium channelsProton and zinc effects on HERG currentsNonglutamate pore residues in ion selection and conduction in voltage-gated Ca2+ channelsLateral interactions in the outer retina.Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currentsStrain differences in pH-sensitive K+ channel-expressing cells in chemosensory and nonchemosensory brain stem nuclei.Synaptic transmission at retinal ribbon synapsesProton-mediated block of Ca2+ channels during multivesicular release regulates short-term plasticity at an auditory hair cell synapse.Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na⁺/H⁺ exchanger NHE5Acid potentiation of the capsaicin receptor determined by a key extracellular siteInfluence of pH on Ca²⁺ current and its control of electrical and Ca²⁺ signaling in ventricular myocytes.Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.Monovalent permeability, rectification, and ionic block of store-operated calcium channels in Jurkat T lymphocytesExtracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel alpha1G (CaV3.1)Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages.The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors.On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sievingProperties of a novel pH-dependent Ca2+ permeation pathway present in male germ cells with possible roles in spermatogenesis and mature sperm function.Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channelIon interactions in the high-affinity binding locus of a voltage-gated Ca(2+) channel.The EEEE locus is the sole high-affinity Ca(2+) binding structure in the pore of a voltage-gated Ca(2+) channel: block by ca(2+) entering from the intracellular pore entrance.Molecular tuning of an EF-hand-like calcium binding loop. Contributions of the coordinating side chain at loop position 3.Ionic selectivity in L-type calcium channels by electrostatics and hard-core repulsionProton inhibition of unitary currents of vanilloid receptors.Mitochondrial Ca2+ sequestration and precipitation revisited.Proton production, regulation and pathophysiological roles in the mammalian brainAcidification of the synaptic cleft of cone photoreceptor terminal controls the amount of transmitter release, thereby forming the receptive field surround in the vertebrate retina.
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Molecular basis of proton block of L-type Ca2+ channels
@ast
Molecular basis of proton block of L-type Ca2+ channels
@en
type
label
Molecular basis of proton block of L-type Ca2+ channels
@ast
Molecular basis of proton block of L-type Ca2+ channels
@en
prefLabel
Molecular basis of proton block of L-type Ca2+ channels
@ast
Molecular basis of proton block of L-type Ca2+ channels
@en
P2093
P2860
P356
P1476
Molecular basis of proton block of L-type Ca2+ channels
@en
P2093
P2860
P304
P356
10.1085/JGP.108.5.363
P577
1996-11-01T00:00:00Z