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Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels.Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological propertiesI SA channel complexes include four subunits each of DPP6 and Kv4.2Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological featuresM-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemiaImmunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculatureHyperinsulinemic Hypoglycemia - The Molecular MechanismsPharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agentsMolecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotidesClassification of H₂O₂as a neuromodulator that regulates striatal dopamine release on a subsecond time scaleKATP channels and cardiovascular disease: suddenly a syndromeA novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channelsA heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac deathAssembly limits the pharmacological complexity of ATP-sensitive potassium channelsMechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoAATP-sensitive potassium channels in capillaries isolated from guinea-pig heartATP interaction with the open state of the K(ATP) channel.Interaction of stilbene disulphonates with cloned K(ATP) channelsEffects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channelGlimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channelsExpression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heartPregabalin attenuates excitotoxicity in diabetesNovel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces.Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactionsProximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channelsSulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridgeInhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes.Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits.Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?Hyperinsulinism induced by targeted suppression of beta cell KATP channels.Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.Chemical tools for K(+) channel biology.Voltage-dependent gating in a "voltage sensor-less" ion channel.Quaternary structure of KATP channel SUR2A nucleotide binding domains resolved by synchrotron radiation X-ray scattering.Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinismStimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction.
P2860
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P2860
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Octameric stoichiometry of the KATP channel complex.
@ast
Octameric stoichiometry of the KATP channel complex.
@en
type
label
Octameric stoichiometry of the KATP channel complex.
@ast
Octameric stoichiometry of the KATP channel complex.
@en
prefLabel
Octameric stoichiometry of the KATP channel complex.
@ast
Octameric stoichiometry of the KATP channel complex.
@en
P2860
P356
P1476
Octameric stoichiometry of the KATP channel complex.
@en
P2093
P2860
P304
P356
10.1085/JGP.110.6.655
P577
1997-12-01T00:00:00Z