Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect
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A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channelStructural and functional characterization of transmembrane segment IX of the NHE1 isoform of the Na+/H+ exchangerIdentification of putative potassium channel homologues in pathogenic protozoaLysine-rich extracellular rings formed by hbeta2 subunits confer the outward rectification of BK channels.The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channelA permeation theory for single-file ion channels: one- and two-step models.Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume.Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.K+ channel selectivity depends on kinetic as well as thermodynamic factors.The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties.Channel-mediated potassium uptake in Helicobacter pylori is essential for gastric colonization.The contribution of RCK domains to human BK channel allosteric activationRelative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.Relationship between pore occupancy and gating in BK potassium channels.Control of single channel conductance in the outer vestibule of the Kv2.1 potassium channelModes of operation of the BKCa channel beta2 subunit.Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block.Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.Molecular mechanisms of BK channel activation.Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor.Allosteric interactions and the modular nature of the voltage- and Ca2+-activated (BK) channel.K(+) channels: function-structural overview.Molecular Determinants of BK Channel Functional Diversity and Functioning.Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore.The protonation state of the Glu-71/Asp-80 residues in the KcsA potassium channel: a first-principles QM/MM molecular dynamics study.Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Functional characterization of the transmembrane segment VII of the NHE1 isoform of the Na+/H+ exchanger.BK channel inhibition by strong extracellular acidificationHarnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances
P2860
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P2860
Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Regulation of K+ flow by a rin ...... external surface charge effect
@ast
Regulation of K+ flow by a rin ...... external surface charge effect
@en
type
label
Regulation of K+ flow by a rin ...... external surface charge effect
@ast
Regulation of K+ flow by a rin ...... external surface charge effect
@en
prefLabel
Regulation of K+ flow by a rin ...... external surface charge effect
@ast
Regulation of K+ flow by a rin ...... external surface charge effect
@en
P2093
P2860
P356
P1476
Regulation of K+ flow by a rin ...... external surface charge effect
@en
P2093
Daniel Sigg
Enrico Stefani
Ligia Toro
Riccardo Olcese
Sergio Ciani
Trude Haug
P2860
P304
P356
10.1085/JGP.200308949
P577
2004-08-01T00:00:00Z