Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743.
about
Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarineDNA and the chromosome - varied targets for chemotherapyCancer wars: natural products strike backAlkaloids from marine invertebrates as important leads for anticancer drugs discovery and developmentAntineoplastic agents from natural sources: achievements and future directions.The p14ARF alternate reading frame protein enhances DNA binding of topoisomerase I by interacting with the serine 506-phosphorylated core domain.Natural products from marine organisms and their associated microbes.Microarray-based transcriptional profiling of renieramycin M and jorunnamycin C, isolated from Thai marine organisms.Natural product drug discovery in the next millennium.Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.ET743: Chemical analysis of the sea squirt Ecteinascidia turbinata ecosystem.Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblastsEcteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation.Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove.Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.Regioselectivity of Pictet-Spengler Cyclization Reactions to Construct the Pentacyclic Frameworks of the Ecteinascidin-Saframycin Class of Tetrahydroisoquinoline Antitumor Antibiotics.Identification of GAPDH as a protein target of the saframycin antiproliferative agents.Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.Anticancer agent-based marine natural products and related compounds.Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.Asymmetric synthesis of (-)-renieramycin T.Design of Organic Transformations at Ambient Conditions: Our Sincere Efforts to the Cause of Green Chemistry Practice.Synthesis, spectroscopic characterization, X-ray analysis and theoretical studies on the spectral features (FT-IR, 1H-NMR), chemical reactivity, NBO analyses of 2-(4-fluorophenyl)-2-(4-fluorophenylamino)acetonitrile and its docking into IDO enzymeA Comparison Between Catalyst-Free and ZrOCl2⋅8H2O-Catalyzed Strecker Reactions for the Rapid and Solvent-Free One-Pot Synthesis of Racemic α-Aminonitrile Derivatives
P2860
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P2860
Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Phthalascidin, a synthetic ant ...... mparable to ecteinascidin 743.
@ast
Phthalascidin, a synthetic ant ...... mparable to ecteinascidin 743.
@en
type
label
Phthalascidin, a synthetic ant ...... mparable to ecteinascidin 743.
@ast
Phthalascidin, a synthetic ant ...... mparable to ecteinascidin 743.
@en
prefLabel
Phthalascidin, a synthetic ant ...... mparable to ecteinascidin 743.
@ast
Phthalascidin, a synthetic ant ...... mparable to ecteinascidin 743.
@en
P2093
P2860
P356
P1476
Phthalascidin, a synthetic ant ...... mparable to ecteinascidin 743.
@en
P2093
E J Martinez
S L Schreiber
P2860
P304
P356
10.1073/PNAS.96.7.3496
P407
P577
1999-03-01T00:00:00Z