NEDD4-mediated HSF1 degradation underlies α-synucleinopathy. - Wikidata - wikimedia - TriplyDB

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

http://www.wikidata.org/entity/Q36444580

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Regulation of the mammalian heat shock factor 1.Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.The central role of heat shock factor 1 in synaptic fidelity and memory consolidation Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.Protein misfolding in neurodegenerative diseases: implications and strategies.Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.Pseudoexfoliation and Alzheimer's associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression.Rethinking HSF1 in Stress, Development, and Organismal Health.Regulation of heat shock transcription factors and their roles in physiology and disease.

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P2860

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

http://www.wikidata.org/entity/Q36444580

description

2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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name

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

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NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

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type

label

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

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NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

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prefLabel

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

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NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

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Human Molecular Genetics

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NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

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Bin Wang

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Eliezer Masliah

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Eunhee Kim

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Francesca-Fang Liao

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Peter T Nelson

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P2860

Molecular chaperones as HSF1-specific transcriptional repressors

Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

HSF1 granules: a novel stress-induced nuclear compartment of human cells

Regulation of HSF1 function in the heat stress response: implications in aging and disease

Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment

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211-222

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scholarly article

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10.1093/HMG/DDV445

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2

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25

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Namratha Sastry

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