Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle - Wikidata - wikimedia - TriplyDB

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle

http://www.wikidata.org/entity/Q36445260

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Targeting G protein coupled receptor-related pathways as emerging molecular therapies Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model.Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma.Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease.Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent.Development and characterization of pepducins as Gs-biased allosteric agonists.Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle.Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells.Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.Therapeutic potential of β-arrestin- and G protein-biased agonists.Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling Physiological and pharmacological implications of beta-arrestin regulation.Airway smooth muscle in airway reactivity and remodeling: what have we learned?beta-Adrenoceptor inverse agonists in asthma New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.cAMP regulation of airway smooth muscle function.β-Arrestins in the immune system β-Arrestins 1 and 2 are critical regulators of inflammation.GPCRs and arrestins in airways: implications for asthma.β2 Agonists Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor.Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor.Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.

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Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle

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Barbara S Theriot

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Deepak A Deshpande

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Julia K L Walker

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Raymond B Penn

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P2860

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3

Enhanced morphine analgesia in mice lacking beta-arrestin 2

Beta-arrestins and cell signaling

Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors.

The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.

The use of beta-agonists and the risk of death and near death from asthma.

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)

The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification.

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