Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle
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Targeting G protein coupled receptor-related pathways as emerging molecular therapiesReceptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivoRepeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model.Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airwayRole for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma.Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease.Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivoAnti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent.Development and characterization of pepducins as Gs-biased allosteric agonists.Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathwaysSalmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe AsthmaGenetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma ModelSpecificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pHA-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle.Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells.Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.Therapeutic potential of β-arrestin- and G protein-biased agonists.Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signalingPhysiological and pharmacological implications of beta-arrestin regulation.Airway smooth muscle in airway reactivity and remodeling: what have we learned?beta-Adrenoceptor inverse agonists in asthmaNew perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.cAMP regulation of airway smooth muscle function.β-Arrestins in the immune systemβ-Arrestins 1 and 2 are critical regulators of inflammation.GPCRs and arrestins in airways: implications for asthma.β2 AgonistsBronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin responseEndogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitizationStructure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor.Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor.Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.
P2860
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P2860
Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Beta-arrestins specifically co ...... nction in airway smooth muscle
@ast
Beta-arrestins specifically co ...... nction in airway smooth muscle
@en
type
label
Beta-arrestins specifically co ...... nction in airway smooth muscle
@ast
Beta-arrestins specifically co ...... nction in airway smooth muscle
@en
prefLabel
Beta-arrestins specifically co ...... nction in airway smooth muscle
@ast
Beta-arrestins specifically co ...... nction in airway smooth muscle
@en
P2093
P2860
P356
P1433
P1476
Beta-arrestins specifically co ...... nction in airway smooth muscle
@en
P2093
Barbara S Theriot
Deepak A Deshpande
Julia K L Walker
Raymond B Penn
P2860
P304
P356
10.1096/FJ.07-102459
P407
P577
2008-03-12T00:00:00Z