Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery
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Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic ApplicationsDevelopment of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based ConstructsCircumventing antivector immunity: potential use of nonhuman adenoviral vectorsAdenoviral vectors as novel vaccines for influenza.Hexon hypervariable region-modified adenovirus type 5 (Ad5) vectors display reduced hepatotoxicity but induce T lymphocyte phenotypes similar to Ad5 vectorsFirst-in-human evaluation of a hexon chimeric adenovirus vector expressing HIV-1 Env (IPCAVD 002)Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cellsAd5/48 hexon oncolytic virus expressing sTGFβRIIFc produces reduced hepatic and systemic toxicities and inhibits prostate cancer bone metastases.Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in miceA vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth.A Novel Vaccine Approach for Chagas Disease Using Rare Adenovirus Serotype 48 Vectors.Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies.CD46-mediated transduction of a species D adenovirus vaccine improves mucosal vaccine efficacy.The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery.Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction.Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens.Fiber-modified hexon-chimeric oncolytic adenovirus targeting cancer associated fibroblasts inhibits tumor growth in gastric carcinoma.Inhibition of type I interferon responses by adenovirus serotype-dependent Gas6 binding.Hexons from adenovirus serotypes 5 and 48 differentially protect adenovirus vectors from neutralization by mouse and human serum.Oncolytic Adenoviruses in Cancer Treatment.Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.
P2860
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P2860
Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
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2012年學術文章
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2012年學術文章
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name
Ad5:Ad48 hexon hypervariable r ...... following intravenous delivery
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Ad5:Ad48 hexon hypervariable r ...... following intravenous delivery
@en
type
label
Ad5:Ad48 hexon hypervariable r ...... following intravenous delivery
@ast
Ad5:Ad48 hexon hypervariable r ...... following intravenous delivery
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prefLabel
Ad5:Ad48 hexon hypervariable r ...... following intravenous delivery
@ast
Ad5:Ad48 hexon hypervariable r ...... following intravenous delivery
@en
P2093
P2860
P50
P356
P1433
P1476
Ad5:Ad48 hexon hypervariable r ...... following intravenous delivery
@en
P2093
Andrew H Baker
Angela C Bradshaw
Hollie Robinson
Jerome Custers
Katie White
Nico Van Roijen
P2860
P304
P356
10.1038/MT.2012.162
P577
2012-08-28T00:00:00Z