Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
about
TRPV1: on the road to pain reliefEffects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assayAcidification of rat TRPV1 alters the kinetics of capsaicin responses.Differential regulation of proton-sensitive ion channels by phospholipids: a comparative study between ASICs and TRPV1Engineering vanilloid-sensitivity into the rat TRPV2 channelInteraction with phosphoinositides confers adaptation onto the TRPV1 pain receptor.Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity.Kinetic and energetic analysis of thermally activated TRPV1 channelsThermodynamics of heat activation of single capsaicin ion channels VR1.Acid-sensitive ion channels and receptorsTransient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli.Proton block of proton-activated TRPV1 current.Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.Potentiation of TRPM7 inward currents by protonsAn external sodium ion binding site controls allosteric gating in TRPV1 channelsThe pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensorProton inhibition of unitary currents of vanilloid receptors.Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.Moving towards supraspinal TRPV1 receptors for chronic pain reliefCurrent perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications.The science of migraine.Transient receptor potentials (TRPs) and anaphylaxis.Molecular mechanism of TRP channelsTyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics.Capsaicin and Its Role in Chronic Diseases.TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells.Conjugated polymers mediate effective activation of the Mammalian Ion Channel Transient Receptor Potential Vanilloid 1.Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor.Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties.Voltage-Dependent Interaction of Capsaicine and Protons on TRPV1-Receptors.Modulation of single-channel properties of TRPV1 by phosphorylation.Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic pain.Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors.Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1.Calcium-sensing receptor in rat vagal bronchopulmonary sensory neurons regulates the function of the capsaicin receptor TRPV1.TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons.Intracellular acidification evoked by moderate extracellular acidosis attenuates transient receptor potential V1 (TRPV1) channel activity in rat dorsal root ganglion neurons.Heat activation is intrinsic to the pore domain of TRPV1.
P2860
Q24650367-C22BF607-27D9-447F-9907-DE43CA26B7BBQ24670592-9669B739-7AD9-444F-B8CE-ADBB94DD65DBQ24672180-8D8D9CA1-815C-4460-A2D3-1D4886705922Q24815927-05864FB2-0B60-4CF8-9BB4-31EEE01F52DFQ28544410-C8165E92-2A3D-44E0-85C2-C785D73E5FD5Q28830324-816024F6-2455-4E13-AADA-C3B29B61F3C0Q33412519-422008D7-724F-4585-A562-86AD9820835BQ33590332-A090713D-A045-4390-BD51-AFB07387813EQ34134625-DAB47B34-0905-469D-B3AB-342208FB2B44Q34183505-31AAF2EC-D47C-4A79-AD93-C18681AC6DF5Q35178189-9EE5BDC1-9D14-42D1-81FF-790C8FBE62B5Q35230235-85029BDC-D952-4A7C-BC2A-72606CB57FC1Q35582277-135808CF-10EE-4661-BA76-EE5D209FDEA2Q35894332-BC9BBB14-8E56-46B9-BEF7-8B87ECF9129EQ36291709-57FB7560-2CEC-4E02-8E4B-5124B9261677Q36493502-DB8BAC48-652E-4E63-BC88-35E621E018DFQ36610027-9FFCEB12-987D-4925-BDA0-852CB46CE882Q37023861-873C5291-FEE7-40AC-A315-ECBABAB336F0Q37331670-6D98C807-DCD4-4470-9286-2257D94CF0D1Q37585521-C5BA60CF-88E8-416F-BCE9-52C6544363CEQ37799398-5BB2B598-C186-4182-80A6-1CCEC9C3F7B6Q37960107-63786470-AD4F-46DC-8EE6-12CC4CB875C3Q37986274-F54DCDDC-486D-4D22-AFD1-96F916D16957Q38042845-877B9340-9AC5-42E3-B5CA-40F9FEF93D14Q38110511-80854675-6D52-4AE5-A07B-D453196DBF0CQ38773336-C2D6596D-ED49-4719-819D-897696F70E8CQ38988562-8318AA31-CB3F-441C-838C-76218F6268FAQ40224259-1C4F66C1-3385-47E6-8791-C25EA12A4EAFQ41437118-44490583-B0F3-4F3D-8A05-386784437791Q41955641-569B1FF9-AE26-4391-8C88-4A73CB860EDCQ41969847-AC0AEF50-3721-4A72-9CA7-7D17DF9BA209Q42290409-3C1A5223-0D88-4726-BA12-4986F7B7875FQ42943379-1FD04085-2D05-4EE2-91AE-89D9BDF7A6B0Q44796548-D3ADAB66-17FD-40F2-AEB3-3719C159EB7AQ45064242-72F41876-9D25-4BF8-8DE0-D6FE8ABEAC14Q45129816-9BEB79DB-9BCB-4A36-AAD8-6E6BE2B3146CQ46692341-530A12EC-40D5-41F0-8D3F-6230834CA256Q48387642-3D1C0A1F-18AD-4CCF-A5E4-6B07AFCE2F5BQ48890576-6688C1AB-4B16-4F80-879E-F6169AC33669Q49197613-31D2FFFC-8E20-4BAB-937C-619DDB174DD6
P2860
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
@ast
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
@en
type
label
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
@ast
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
@en
prefLabel
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
@ast
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
@en
P2093
P2860
P356
P1476
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.
@en
P2093
P2860
P356
10.1085/JGP.200308847
P577
2003-07-01T00:00:00Z