Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing. - Wikidata - wikimedia - TriplyDB

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

http://www.wikidata.org/entity/Q36447234

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Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel Molecular mechanisms of large-conductance ca (2+) -activated potassium channel activation by ginseng gintonin Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel Regulation of bestrophin Cl channels by calcium: role of the C terminus The RCK2 domain of the human BKCa channel is a calcium sensor Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls BK channels: multiple sensors, one activation gate Regulation of bestrophins by Ca2+: a theoretical and experimental study.Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain.A BK (Slo1) channel journey from molecule to physiology.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements The TMEM16 protein family: a new class of chloride channels?A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.Ion sensing in the RCK1 domain of BK channels.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel Tuning magnesium sensitivity of BK channels by mutations.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.The contribution of RCK domains to human BK channel allosteric activation Barium ions selectively activate BK channels via the Ca2+-bowl site Interaction of the BKCa channel gating ring with dendrotoxins.Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism.A tail of multiple calcium-sensing domains Mechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channel A role for the S0 transmembrane segment in voltage-dependent gating of BK channels.Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains.Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels.Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity is enhanced by its beta1 subunit BK Channels in Cardiovascular Diseases and Aging State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels

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P2860

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

http://www.wikidata.org/entity/Q36447234

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

@ast

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

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type

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Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

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Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

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prefLabel

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

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Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

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The Journal of General Physiology

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Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.

@en

P2093

Christina Kaldany

http://www.w3.org/2001/XMLSchema#string

Daniel H Cox

http://www.w3.org/2001/XMLSchema#string

Ericka C Holmstrand

http://www.w3.org/2001/XMLSchema#string

Lin Bao

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P2860

X-ray structure of a voltage-dependent K+ channel

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

A novel calcium-sensing domain in the BK channel.

The C2 domain calcium-binding motif: structural and functional diversity

Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms

Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel

Crystal structure and mechanism of a calcium-gated potassium channel

Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke

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475-489

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10.1085/JGP.200409052

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5

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123

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2004-05-01T00:00:00Z

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2234491

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