A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. - Wikidata - wikimedia - TriplyDB

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.

http://www.wikidata.org/entity/Q36447915

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CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives The many faces of histone H3K79 methylation The complexity of epigenetic diseases Chemical probes of histone lysine methyltransferases Targets, models and challenges in osteoarthritis research Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Cancer epigenetics drug discovery and development: the challenge of hitting the mark Hijacked in cancer: the KMT2 (MLL) family of methyltransferases Potent inhibition of DOT1L as treatment of MLL-fusion leukemia Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets Epigenome-based personalized medicine in human cancer BET domain co-regulators in obesity, inflammation and cancer Misguided transcriptional elongation causes mixed lineage leukemia Human ALKBH4 interacts with proteins associated with transcription Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4 Novel motifs distinguish multiple homologues of Polycomb in vertebrates: expansion and diversification of the epigenetic toolkit Emerging drugs for chronic myeloid leukemia.Effects of RNAi-mediated knockdown of histone methyltransferases on the sex-specific mRNA expression of Imp in the silkworm Bombyx mori.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.Polycomb and trithorax opposition in development and disease.A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Quantitative proteomic discovery of dynamic epigenome changes that control human cytomegalovirus (HCMV) infection Leukaemogenesis: more than mutant genes

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A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.

http://www.wikidata.org/entity/Q36447915

description

2007 nî lūn-bûn

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

A role for the MLL fusion part ...... on and chromatin modification.

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A role for the MLL fusion part ...... on and chromatin modification.

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type

label

A role for the MLL fusion part ...... on and chromatin modification.

@ast

A role for the MLL fusion part ...... on and chromatin modification.

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prefLabel

A role for the MLL fusion part ...... on and chromatin modification.

@ast

A role for the MLL fusion part ...... on and chromatin modification.

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A role for the MLL fusion part ...... on and chromatin modification.

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Arul Chinnaiyan

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Arun Sreekumar

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Deniz Zeisig

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Dorothee Mueller

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Jay L Hess

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Maria-Paz Garcia-Cuellar

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Robert K Slany

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Rong Zhou

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Sara Monroe

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P2860

BCoR, a novel corepressor involved in BCL-6 repression

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

Probability-based protein identification by searching sequence databases using mass spectrometry data

hDOT1L links histone methylation to leukemogenesis.

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties

A statistical model for identifying proteins by tandem mass spectrometry

MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein

The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias

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4445-4454

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10.1182/BLOOD-2007-05-090514

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13

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110

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Alexey I. Nesvizhskii

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2007-09-12T00:00:00Z

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5984336

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17855633

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