The effect of long term calorie restriction on in vivo hepatic proteostatis: a novel combination of dynamic and quantitative proteomics
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The measurement of protein synthesis for assessing proteostasis in studies of slowed agingA large dataset of protein dynamics in the mammalian heart proteomeAltered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans.Mitochondria are required for pro-ageing features of the senescent phenotype.Mechanisms of In Vivo Ribosome Maintenance Change in Response to Nutrient Signals.Turnover rates of hepatic collagen and circulating collagen-associated proteins in humans with chronic liver diseaseRespiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effectsCirculating protein synthesis rates reveal skeletal muscle proteome dynamics.Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity.Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.Spatial and temporal dynamics of the cardiac mitochondrial proteome.Mitochondrial protein turnover: methods to measure turnover rates on a large scale.Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria.Protein kinetic signatures of the remodeling heart following isoproterenol stimulation.Cardiac mitochondrial proteome dynamics with heavy water reveals stable rate of mitochondrial protein synthesis in heart failure despite decline in mitochondrial oxidative capacity.Applications of deuterium oxide in human health.Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics.A pilot study demonstrating a non-invasive method for the measurement of protein turnover in skin disorders: application to psoriasis.Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment.Integrated omics dissection of proteome dynamics during cardiac remodeling.Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation.Protein Turnover in Aging and Longevity.
P2860
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P2860
The effect of long term calorie restriction on in vivo hepatic proteostatis: a novel combination of dynamic and quantitative proteomics
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
The effect of long term calori ...... ic and quantitative proteomics
@ast
The effect of long term calori ...... ic and quantitative proteomics
@en
type
label
The effect of long term calori ...... ic and quantitative proteomics
@ast
The effect of long term calori ...... ic and quantitative proteomics
@en
prefLabel
The effect of long term calori ...... ic and quantitative proteomics
@ast
The effect of long term calori ...... ic and quantitative proteomics
@en
P2093
P2860
P356
P1476
The effect of long term calori ...... ic and quantitative proteomics
@en
P2093
Cyrus F Khambatta
John C Price
Kelvin W Li
Lindsay S Roberts
Mahalakshmi Shankaran
Marc K Hellerstein
Marcy Dalidd
Matthew D Bruss
Nicholas A Floreani
Scott M Turner
P2860
P304
P356
10.1074/MCP.M112.021204
P577
2012-09-13T00:00:00Z