Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression - Wikidata - wikimedia - TriplyDB

Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression

Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression

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SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site Sumoylation in gene regulation, human disease, and therapeutic action.Base Excision Repair, a Pathway Regulated by Posttranslational Modifications SUMO-mediated regulation of DNA damage repair and responses Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1 The coming of age of phosphoproteomics--from large data sets to inference of protein functions C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2 Interacting partners of FEN1 and its role in the development of anticancer therapeutics.Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.YY1 suppresses FEN1 over-expression and drug resistance in breast cancer The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.Sumoylation regulates EXO1 stability and processing of DNA damage.SUMOylation of TARBP2 regulates miRNA/siRNA efficiency.Sequential posttranslational modifications regulate PKC degradation.Okazaki fragment metabolism.It takes two to tango: Ubiquitin and SUMO in the DNA damage response.Flap endonuclease 1.Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination Lysine Acetylation and Succinylation in HeLa Cells and their Essential Roles in Response to UV-induced Stress.Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Regulation of Wnt/β-catenin signaling by posttranslational modifications BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex.Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.Dynamic ubiquitin signaling in cell cycle regulation.DNA end resection requires constitutive sumoylation of CtIP by CBX4.Comprehensive mutational analysis reveals p6Gag phosphorylation to be dispensable for HIV-1 morphogenesis and replication The SMX DNA Repair Tri-nuclease.Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.PKC SUMOylation inhibits the binding of 14-3-3τ to GluK2.Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins.Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.Maneuvers on PCNA Rings during DNA Replication and Repair SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress

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Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression

http://www.wikidata.org/entity/Q36456251

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Binghui Shen

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Changwei Liu

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Claudia Kowolik

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Joonas Jamsen

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Julie Kanjanapangka

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Khue Truong

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Li Zheng

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Mian Zhou

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Na Liu

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Songbai Liu

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P2860

Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

A new NEDD8-ligating system for cullin-4A

Polymerase dynamics at the eukaryotic DNA replication fork

The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis

Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

The DNA replication fork in eukaryotic cells.

Cyclin is degraded by the ubiquitin pathway

Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3

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