Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.

Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.

Item
http://www.wikidata.org/entity/Q36457138
Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor.The strictly conserved Arg-321 residue in the active site of Escherichia coli topoisomerase I plays a critical role in DNA rejoining.Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II)Use of double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex.SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway.Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region.Bacterial topoisomerase I as a target for discovery of antibacterial compounds.Hydroxyl radicals are involved in cell killing by the bacterial topoisomerase I cleavage complex.Effects of magnesium and related divalent metal ions in topoisomerase structure and function.Asp-to-Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli.A highly processive topoisomerase I: studies at the single-molecule level.Inhibition of type IA topoisomerase by a monoclonal antibody through perturbation of DNA cleavage-religation equilibrium.The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates
P2860

Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.

Item
http://www.wikidata.org/entity/Q36457138
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
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name
Mutation adjacent to the activ ...... of bacterial topoisomerase I.
@ast
Mutation adjacent to the activ ...... of bacterial topoisomerase I.
@en
type
label
Mutation adjacent to the activ ...... of bacterial topoisomerase I.
@ast
Mutation adjacent to the activ ...... of bacterial topoisomerase I.
@en
prefLabel
Mutation adjacent to the activ ...... of bacterial topoisomerase I.
@ast
Mutation adjacent to the activ ...... of bacterial topoisomerase I.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Mutation adjacent to the activ ...... of bacterial topoisomerase I.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932