Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

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http://www.wikidata.org/entity/Q36458742

Q36458742

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p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance Proteomic and genomic analysis of PITX2 interacting and regulating networks Surmounting chemoresistance by targeting the Y-box binding protein-1 Extracellular Signal-regulated Kinase (ERK)-dependent Phosphorylation of Y-Box-binding Protein 1 (YB-1) Enhances Gene Expression in Granulosa Cells in Response to Follicle-stimulating Hormone (FSH)RSK in tumorigenesis: connections to steroid signaling.Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer.YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification Unraveling breast cancer heterogeneity through transcriptomic and epigenomic analysis.Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.A novel recombinant papillomavirus genome enabling in vivo RNA interference reveals that YB-1, which interacts with the viral regulatory protein E2, is required for CRPV-induced tumor formation in vivo Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1.Prognostic association of YB-1 expression in breast cancers: a matter of antibody.Identification and characterization of a novel integrin-linked kinase inhibitor Calcineurin-mediated YB-1 dephosphorylation regulates CCL5 expression during monocyte differentiation.Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability.Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells.The cancerous translation apparatus Lapatinib in combination with radiation diminishes tumor regrowth in HER2+ and basal-like/EGFR+ breast tumor xenografts.Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1 Characteristics of triple-negative breast cancer Basal-like phenotype in a breast carcinoma case series from Sudan: prevalence and clinical/pathological correlations.Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.Prognostic role of YB-1 expression in breast cancer: a meta-analysis Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation.Expression of Y-box-binding protein YB-1 allows stratification into long- and short-term survivors of head and neck cancer patients Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer Translational control in cancer etiology.Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer.Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes.Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer.Radiation-induced gene signature predicts pathologic complete response to neoadjuvant chemotherapy in breast cancer patients Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors Biomarkers for Basal-like Breast Cancer.C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells.Y-box binding protein-1 promotes hepatocellular carcinoma-initiating cell progression and tumorigenesis via Wnt/β-catenin pathway.

P2860

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P2860

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

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2007 nî lūn-bûn

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Epidermal growth factor recept ...... potential target for therapy.

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P2860

Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

The human genome browser at UCSC

SeeGH--a software tool for visualization of whole genome array comparative genomic hybridization data

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Gene expression profiling predicts clinical outcome of breast cancer

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Molecular portraits of human breast tumours

Repeated observation of breast tumor subtypes in independent gene expression data sets

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Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

about

P2860

P2860

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

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