Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor
about
Cardiovascular effects of glucagon-like peptide 1 (GLP-1) receptor agonistsPositive allosteric modulators to peptide GPCRs: a promising class of drugsTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsLow-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibilityPositive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse ElectrophilesA comparison of three (67/68)Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelatorEvolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversificationTargeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.Polymorphisms of GLP-1 receptor gene and response to GLP-1 analogue in patients with poorly controlled type 2 diabetes.GLP-1 based therapeutics: simultaneously combating T2DM and obesity.Emergence of Chinese drug discovery research: impact of hit and lead identification.Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and GlucagonCardiovascular Benefits of Native GLP-1 and its Metabolites: An Indicator for GLP-1-Therapy Strategies.Application of chemical biology in target identification and drug discovery.Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.Fluorescent exendin-4 derivatives for pancreatic β-cell analysis.The predicted ensemble of low-energy conformations of human somatostatin receptor subtype 5 and the binding of antagonists.Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor.Conformational and Thermodynamic Landscape of GPCR Activation from Theory and Computation.
P2860
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P2860
Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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@zh-sg
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name
Predicted structure of agonist ...... s B G protein-coupled receptor
@ast
Predicted structure of agonist ...... s B G protein-coupled receptor
@en
type
label
Predicted structure of agonist ...... s B G protein-coupled receptor
@ast
Predicted structure of agonist ...... s B G protein-coupled receptor
@en
prefLabel
Predicted structure of agonist ...... s B G protein-coupled receptor
@ast
Predicted structure of agonist ...... s B G protein-coupled receptor
@en
P2093
P2860
P356
P1476
Predicted structure of agonist ...... s B G protein-coupled receptor
@en
P2093
Andrea Kirkpatrick
Jiyoung Heo
William A Goddard
P2860
P304
19988-19993
P356
10.1073/PNAS.1218051109
P407
P577
2012-11-19T00:00:00Z