Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer

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RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells.

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Q47955849-07F44597-734C-4AD5-9871-C4F281D53F43 Q48124146-E1A4741F-1668-4ADB-9836-24F25892E7F5

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Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer

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http://www.wikidata.org/entity/Q36471294

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Rad6 upregulation promotes ste ...... m resistance in ovarian cancer

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Rad6 upregulation promotes ste ...... m resistance in ovarian cancer

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Rad6 upregulation promotes ste ...... m resistance in ovarian cancer

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Rad6 upregulation promotes ste ...... m resistance in ovarian cancer

@en

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Rad6 upregulation promotes ste ...... m resistance in ovarian cancer

@ast

Rad6 upregulation promotes ste ...... m resistance in ovarian cancer

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Rad6 upregulation promotes ste ...... m resistance in ovarian cancer

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David W Clark

http://www.w3.org/2001/XMLSchema#string

Gary A Piazza

http://www.w3.org/2001/XMLSchema#string

Jennifer Scalici

http://www.w3.org/2001/XMLSchema#string

Komaraiah Palle

http://www.w3.org/2001/XMLSchema#string

Lavanya Bachaboina

http://www.w3.org/2001/XMLSchema#string

Ranganatha R Somasagara

http://www.w3.org/2001/XMLSchema#string

Rodney P Rocconi

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Sebastian M Spencer

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P2860

ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

Rad6B is a positive regulator of beta-catenin stabilization

RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Cancer statistics, 2013

Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B.

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.

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449-455

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scholarly article

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10.1016/J.BBRC.2015.11.134

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English

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http://www.w3.org/2001/XMLSchema#string

P478

469

http://www.w3.org/2001/XMLSchema#string

P50

Kaushlendra Tripathi

Reagan Barnett

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2015-12-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

26679603

http://www.w3.org/2001/XMLSchema#string

P921

ovarian cancer

P932

4715924

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Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer

about

P2860

P2860

Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932