The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin.
about
Nutritional Signaling via Free Fatty Acid ReceptorsPharmacology and physiology of gastrointestinal enteroendocrine cellsAn enteroendocrine cell-enteric glia connection revealed by 3D electron microscopyIncreased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiotaImmunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretionCorrelative Confocal and 3D Electron Microscopy of a Specific Sensory CellA bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cellsCholecystokinin and pancreatic cancer: the chicken or the egg?Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptorsGut feelings: the emerging biology of gut-brain communication.Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-proteinDuodenal enteroendocrine I-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors.A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.Nutrients differentially regulate nucleobindin-2/nesfatin-1 in vitro in cultured stomach ghrelinoma (MGN3-1) cells and in vivo in male mice.Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1.GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivoStructure-function of CD36 and importance of fatty acid signal transduction in fat metabolismOverexpression of G-protein-coupled receptor 40 enhances the mitogenic response to epoxyeicosatrienoic acidsGut chemosensing mechanisms.Dietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines.The gut connectome: making sense of what you eatIntragastric fat self-administration is impaired in GPR40/120 double knockout mice.Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120.Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calciumSensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion.CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokininRole of the gut in lipid homeostasisGustducin couples fatty acid receptors to GLP-1 release in colon.Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors.Deletion of GPR40 fatty acid receptor gene in mice blocks mercaptoacetate-induced feeding.Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRsThe endocrinology of taste receptors.Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans.Current and emerging concepts on the role of peripheral signals in the control of food intake and development of obesity.Gastrointestinal chemosensation: chemosensory cells in the alimentary tract.Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.The gut endocrine system as a coordinator of postprandial nutrient homoeostasis.Digestive physiology of the pig symposium: G protein-coupled receptors in nutrient chemosensation and gastrointestinal hormone secretion.Food and symptom generation in functional gastrointestinal disorders: physiological aspects.Integration of satiety signals by the central nervous system.
P2860
Q26749828-B98FA5C3-B0DE-407B-AA93-E2700D7C1E92Q26799380-DEC6B1A3-6AA9-4C01-A012-37F97BE47D51Q27319888-77B32879-9518-4DF1-AA46-3A9F5CBE89C9Q28480933-2E5D0F69-0C4E-4254-BBA7-26B0A199636BQ28585605-DFA662D1-D19F-4360-A33F-6B03C81F5826Q28608626-A08C1E57-E8A6-4255-A1E2-E4CABB712052Q28829204-4C99B380-9817-41DA-B00D-A7935F0EAEEEQ33816883-84640DBB-5FEE-40A0-97B8-837F1FF7117DQ34121932-ABE0CC82-B121-4570-B4FD-66F7DAD045ABQ34199959-9D1B0E35-86B0-404A-901B-402501F99E55Q34328732-3CB03871-AB1E-4796-9236-784ACD463C6EQ34372605-BABCB6B4-6F5D-4951-A826-B4E72DF37A3CQ34441309-5CFDD9AE-E9BC-4F38-8893-51407E84F7A0Q34704060-147D48F4-BE64-481E-B772-8397167D3D01Q34979979-256B6F13-05D4-4B2E-BE46-0020529F49F4Q35040481-FF5ACFED-49C9-405F-B565-2075C1E0F807Q35087570-E8901CBE-767D-40E1-8BBE-3185ACF5089DQ35094877-19AEA648-9F04-4610-A266-820B8084A220Q35183915-897C8FA7-1655-4E6E-B9C4-7E8AC70A68BBQ35193895-0027E01E-1DC6-47C4-B8DE-D5587FDDE887Q35242323-C496B23D-9412-47B2-8CA0-29E01695D3F8Q35685138-DA1C7375-DAF7-4082-A791-B5C3A7F9B923Q35687964-BDD8D6C1-5063-4638-AD8E-78B5791D048DQ36095063-F4E8983E-E142-415B-8A03-331EB5620D44Q36593122-EDB8AD47-E95D-4DD1-81DC-CA6E9786E021Q36615196-9CDFCB9C-BB77-4208-A8E1-F2B59A0C370EQ36660888-20578FCB-0C46-40F6-B225-9DC5252A8C3AQ36699764-07FCBC3A-A566-4B19-B7CC-FA98BCD82C8CQ36902607-8007048F-E054-4C16-B428-0DDA29099E32Q36955322-295DED53-7A4F-46A7-B72C-5BCDC714B8BAQ37237145-9CD2ECEB-E5F0-4CE6-A39F-4FA9E21B36E1Q37571440-64194D7E-47AC-4500-AF0B-B68E448BDF42Q37976164-780B6A3C-9DD0-4EC5-85C8-6395E5DC05E7Q37992743-3A92C6DE-1889-45D8-A7CE-C0A91B36C651Q38004925-8BC10730-043F-4036-B603-D6709B39E03DQ38014830-9017908F-2881-438C-BE7D-0E337E04131BQ38036016-D3EC76F6-6839-402F-BCE0-9E6D5717E253Q38066461-84875539-BF41-4AD6-898B-1E6B0C7034D7Q38086347-421953D0-6F5A-4E81-9205-B2FE7016BACEQ38105423-F768F656-2EEE-48B9-85EA-A004833F99F1
P2860
The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
The G-protein-coupled receptor ...... secretion of cholecystokinin.
@ast
The G-protein-coupled receptor ...... secretion of cholecystokinin.
@en
type
label
The G-protein-coupled receptor ...... secretion of cholecystokinin.
@ast
The G-protein-coupled receptor ...... secretion of cholecystokinin.
@en
prefLabel
The G-protein-coupled receptor ...... secretion of cholecystokinin.
@ast
The G-protein-coupled receptor ...... secretion of cholecystokinin.
@en
P2093
P2860
P921
P1433
P1476
The G-protein-coupled receptor ...... secretion of cholecystokinin.
@en
P2093
Alice P Liou
Helen E Raybould
Ricardo J Carrero
Stephen Wank
Susanne Pechhold
Xilin Zhao
Xinping Lu
Yoshitatsu Sei
P2860
P304
P356
10.1053/J.GASTRO.2010.10.012
P407
P577
2010-10-16T00:00:00Z