Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
about
Comparing protein folding in vitro and in vivo: foldability meets the fitness challengeHomotypic clusters of transcription factor binding sites: A model system for understanding the physical mechanics of gene expressionProtein-protein interactions in a crowded environment: an analysis via cross-docking simulations and evolutionary informationDeterminants of the rate of protein sequence evolutionExperimental evolution of protein-protein interaction networksAmino-acid site variability among natural and designed proteinsParallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.Protomers of protein hetero-oligomers tend to resemble each other more than expectedSelection on protein structure, interaction, and sequence.Interplay between chaperones and protein disorder promotes the evolution of protein networks.Protein-protein binding selectivity and network topology constrain global and local properties of interface binding networks.Evolution of specificity in protein-protein interactionsBiophysics of protein evolution and evolutionary protein biophysicsDonut-shaped chambers for analysis of biochemical processes at the cellular and subcellular levels.Deciphering protein stability in cells.Abundance and Temperature Dependency of Protein-Protein Interaction Revealed by Interface Structure Analysis and Stability Evolution.Population size dependence of fitness effect distribution and substitution rate probed by biophysical model of protein thermostability.Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity.Conserved proteins are fragile.Non-interacting proteins may resemble interacting proteins: prevalence and implications.Symbiosomes: temporary moonlighting organelles.Lymphocyte repertoire selection and intracellular self/non-self-discrimination: historical overview.Evolution and Biological Roles of Alternative 3'UTRs.Understanding and predicting protein misfolding and aggregation: Insights from proteomics.Secreted Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation.Chaperone-client interactions: Non-specificity engenders multifunctionality.ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules.Intermediate divergence levels maximize the strength of structure-sequence correlations in enzymes and viral proteins.DSPMP: Discriminating secretory proteins of malaria parasite by hybridizing different descriptors of Chou's pseudo amino acid patterns.Searching for the Pareto frontier in multi-objective protein design.Diffusion within the cytoplasm: a mesoscale model of interacting macromoleculesCatalysis of protein folding by chaperones accelerates evolutionary dynamics in adapting cell populationsAmyloid formation by human carboxypeptidase D transthyretin-like domain under physiological conditions.mRNA-programmed translation pauses in the targeting of E. coli membrane proteinsA Simple Model of Protein Domain Swapping in Crowded Cellular Environments.Essentiality Is a Strong Determinant of Protein Rates of Evolution during Mutation Accumulation Experiments in Escherichia coli.Protein targets of thioacetamide metabolites in rat hepatocytes.Protein structural disorder of the envelope V3 loop contributes to the switch in human immunodeficiency virus type 1 cell tropism.Ribosome surface properties may impose limits on the nature of the cytoplasmic proteome.
P2860
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P2860
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
@ast
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
@en
type
label
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
@ast
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
@en
prefLabel
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
@ast
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
@en
P2860
P50
P356
P1476
Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
@en
P2860
P304
20461-20466
P356
10.1073/PNAS.1209312109
P407
P577
2012-11-26T00:00:00Z