Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.
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Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity.Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-Specific Monoclonal Antibodies.Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface.Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif.Evaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region.Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies.Peripheral Membrane Interactions Boost the Engagement by an Anti-HIV-1 Broadly Neutralizing Antibody.Identification and specificity of broadly neutralizing antibodies against HIVHow HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles.Functional Contacts between MPER and the Anti-HIV-1 Broadly Neutralizing Antibody 4E10 Extend into the Core of the Membrane.Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target.Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem.FUNCTIONAL OPTIMIZATION OF BROADLY NEUTRALIZING HIV-1 ANTIBODY 10E8 BY PROMOTING MEMBRANE INTERACTIONS.Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects.HIV Entry and Its Inhibition by Bifunctional Antiviral ProteinsCo-delivery of a CD4 T cell helper epitope via covalent liposome attachment with a surface-arrayed B cell target antigen fosters higher affinity antibody responses
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P2860
Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
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2016年學術文章
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2016年學術文章
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name
Crystallographic Identificatio ...... ly Neutralizing Antibody 4E10.
@ast
Crystallographic Identificatio ...... ly Neutralizing Antibody 4E10.
@en
type
label
Crystallographic Identificatio ...... ly Neutralizing Antibody 4E10.
@ast
Crystallographic Identificatio ...... ly Neutralizing Antibody 4E10.
@en
prefLabel
Crystallographic Identificatio ...... ly Neutralizing Antibody 4E10.
@ast
Crystallographic Identificatio ...... ly Neutralizing Antibody 4E10.
@en
P2093
P2860
P921
P1433
P1476
Crystallographic Identificatio ...... ly Neutralizing Antibody 4E10.
@en
P2093
Adriana Irimia
Ian A Wilson
Robyn L Stanfield
P2860
P356
10.1016/J.IMMUNI.2015.12.001
P407
P50
P577
2016-01-04T00:00:00Z