The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion.
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Pseudomonas Exotoxin A: optimized by evolution for effective killingToxin-based therapeutic approachesTrends in immunoconjugate and ligand-receptor based targeting development for cancer therapy.Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells.Development of a prolactin receptor-targeting fusion toxin using a prolactin antagonist and a recombinant form of Pseudomonas exotoxin A.Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotoxMisfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome.Affitoxin--a novel recombinant, HER2-specific, anticancer agent for targeted therapy of HER2-positive tumorsImmunoconjugates in the management of hairy cell leukemia.Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignanciesThapsigargin-induced transport of cholera toxin to the endoplasmic reticulum.Endocytosis and intracellular sorting of ricin and Shiga toxin.Clinical targeting recombinant immunotoxins for cancer therapyTranslocation of ricin A-chain into proteoliposomes reconstituted from Golgi and endoplasmic reticulum.Toxin entry: retrograde transport through the secretory pathway.Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga B-fragment is regulated by butyric acid and cAMP.Construction, expression and characterization of chimaeric toxins containing the ribonucleolytic toxin restrictocin: intracellular mechanism of action.Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor.Toward intracellular targeted delivery of cancer therapeutics: progress and clinical outlook for brain tumor therapy.Recombinant toxins in haematologic malignancies and solid tumours.
P2860
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P2860
The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
The N-terminal region of the 3 ...... microsomal membrane insertion.
@ast
The N-terminal region of the 3 ...... microsomal membrane insertion.
@en
type
label
The N-terminal region of the 3 ...... microsomal membrane insertion.
@ast
The N-terminal region of the 3 ...... microsomal membrane insertion.
@en
prefLabel
The N-terminal region of the 3 ...... microsomal membrane insertion.
@ast
The N-terminal region of the 3 ...... microsomal membrane insertion.
@en
P2093
P2860
P356
P1476
The N-terminal region of the 3 ...... microsomal membrane insertion.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.16.7774
P407
P577
1993-08-01T00:00:00Z