Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels.
about
TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpainFunctional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7Charge Shielding of PIP2 by Cations Regulates Enzyme Activity of Phospholipase CDeterminants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1.Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors.Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity.Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.Phosphatidylinositol 4,5-bisphosphate-dependent regulation of the output in lobster olfactory receptor neuronsThe immunological synapse: a dynamic platform for local signaling.Inactivation of TRPM7 kinase activity does not impair its channel function in mice.Reductions in external divalent cations evoke novel voltage-gated currents in sensory neurons.Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanismThe Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7.A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.Activation of TRPM7 channels by small molecules under physiological conditions.Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity.Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels.TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD?Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytesNatural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.TRPM7 channel is regulated by magnesium nucleotides via its kinase domain.Electrostatic interaction of internal Mg2+ with membrane PIP2 Seen with KCNQ K+ channels.2-aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism.TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions.TRP channels and lipids: from Drosophila to mammalian physiology.Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.TRPM7 is regulated by halides through its kinase domainDeletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasisPhosphoinositide regulation of non-canonical transient receptor potential channels.Transient receptor potential channels meet phosphoinositidesRegulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate.Disturbed acid-base transport: an emerging cause of hypertension.Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine.The functional network of ion channels in T lymphocytesThe molecular physiology of CRAC channels.Intracellular pH in the resistance vasculature: regulation and functional implications.TRPM7, the cytoskeleton and neuronal death.
P2860
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P2860
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Charge screening by internal p ...... rundown of TRPM7/MIC channels.
@ast
Charge screening by internal p ...... rundown of TRPM7/MIC channels.
@en
type
label
Charge screening by internal p ...... rundown of TRPM7/MIC channels.
@ast
Charge screening by internal p ...... rundown of TRPM7/MIC channels.
@en
prefLabel
Charge screening by internal p ...... rundown of TRPM7/MIC channels.
@ast
Charge screening by internal p ...... rundown of TRPM7/MIC channels.
@en
P2093
P2860
P356
P1476
Charge screening by internal p ...... rundown of TRPM7/MIC channels.
@en
P2093
J Ashot Kozak
Masayuki Matsushita
Michael D Cahalan
P2860
P304
P356
10.1085/JGP.200509324
P577
2005-11-01T00:00:00Z