Delving deeper: MCL-1's contributions to normal and cancer biology. - Wikidata - wikimedia - TriplyDB

Delving deeper: MCL-1's contributions to normal and cancer biology.

Delving deeper: MCL-1's contributions to normal and cancer biology.

http://www.wikidata.org/entity/Q36494824

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Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4 Targeting Cell Survival Proteins for Cancer Cell Death Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.Mcl-1 ubiquitination: unique regulation of an essential survival protein.Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth.The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70 Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer.MiR-29a promotes intestinal epithelial apoptosis in ulcerative colitis by down-regulating Mcl-1 MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis.Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation.Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy.Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1).Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1 MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.Chidamide Inhibits Aerobic Metabolism to Induce Pancreatic Cancer Cell Growth Arrest by Promoting Mcl-1 Degradation Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2 Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death Nuclear TRAF3 is a negative regulator of CREB in B cells.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection.Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors.Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells.Racial differences in microRNA and gene expression in hypertensive women.MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.Dual modulation of MCL-1 and mTOR determines the response to sunitinib.Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified.Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response.Human cytomegalovirus manipulation of latently infected cells.How does metabolism affect cell death in cancer?The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.Mcl-1 as a potential therapeutic target for human hepatocelluar carcinoma.

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Delving deeper: MCL-1's contributions to normal and cancer biology.

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Delving deeper: MCL-1's contributions to normal and cancer biology.

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Delving deeper: MCL-1's contributions to normal and cancer biology.

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Delving deeper: MCL-1's contributions to normal and cancer biology.

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Delving deeper: MCL-1's contributions to normal and cancer biology.

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J.TCB.2012.08.011

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Trends in Cell Biology

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Delving deeper: MCL-1's contributions to normal and cancer biology.

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Joseph T Opferman

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Rhonda M Perciavalle

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Hallmarks of Cancer: The Next Generation

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

Brick by brick: metabolism and tumor cell growth

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

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23026029

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proto-oncogene proteins

neoplasm proteins

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3532576

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