Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis.
about
A faulty interaction between SOD1 and hCCS in neurodegenerative diseaseScreening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral SclerosisImmunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis.Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient.Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations.A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation.ApoSOD1 lacking dismutase activity neuroprotects motor neurons exposed to beta-methylamino-L-alanine through the Ca2+/Akt/ERK1/2 prosurvival pathway.Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.Nanoscale Dynamics of Amyloid β-42 Oligomers As Revealed by High-Speed Atomic Force Microscopy.Cysteine to Serine Conversion at 111th Position Renders the Disaggregation and Retains the Stabilization of Detrimental SOD1 A4V Mutant Against Amyotrophic Lateral Sclerosis in Human-A Discrete Molecular Dynamics Study.Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms.A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis.Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosisHigh-speed atomic force microscopy reveals structural dynamics of α-synuclein monomers and dimers
P2860
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P2860
Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Nonnative SOD1 trimer is toxic ...... amyotrophic lateral sclerosis.
@ast
Nonnative SOD1 trimer is toxic ...... amyotrophic lateral sclerosis.
@en
type
label
Nonnative SOD1 trimer is toxic ...... amyotrophic lateral sclerosis.
@ast
Nonnative SOD1 trimer is toxic ...... amyotrophic lateral sclerosis.
@en
prefLabel
Nonnative SOD1 trimer is toxic ...... amyotrophic lateral sclerosis.
@ast
Nonnative SOD1 trimer is toxic ...... amyotrophic lateral sclerosis.
@en
P2093
P2860
P356
P1476
Nonnative SOD1 trimer is toxic ...... amyotrophic lateral sclerosis.
@en
P2093
Ian P Mercer
James M Fay
Lanette Fee
Mohanish Deshmukh
Rachel L Redler
Yazhong Tao
Yuliang Zhang
Yuri L Lyubchenko
Zhengjian Lv
P2860
P304
P356
10.1073/PNAS.1516725113
P407
P577
2015-12-30T00:00:00Z