Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.

Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.

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http://www.wikidata.org/entity/Q36499756

Q36499756

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The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex Working to Eliminate Cancer Health Disparities from Tobacco: A Review of the National Cancer Institute's Community Networks Program.High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population.Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation.Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.Health effects associated with measured levels of contaminants in the Arctic.Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.Nicotine Metabolite Ratio Is Associated With Lozenge Use But Not Quitting in Smokeless Tobacco Users.Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting.Does ethnic ancestry play a role in smoking?Variation in CYP2A6 Activity and Personalized Medicine.Relationships between smoking behaviors and cotinine levels among two American Indian populations with distinct smoking patterns.Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.Biomarkers of tobacco smoke exposure in racial/ethnic groups at high risk for lung cancer.A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s.

P2860

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P2860

Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.

Item

http://www.wikidata.org/entity/Q36499756

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Alaska Native smokers and smok ...... fic nitrosamine bioactivation.

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Alaska Native smokers and smok ...... fic nitrosamine bioactivation.

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type

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Alaska Native smokers and smok ...... fic nitrosamine bioactivation.

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Alaska Native smokers and smok ...... fic nitrosamine bioactivation.

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Alaska Native smokers and smok ...... fic nitrosamine bioactivation.

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Alaska Native smokers and smok ...... fic nitrosamine bioactivation.

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P1476

Alaska Native smokers and smok ...... fic nitrosamine bioactivation.

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P2093

Andy Z X Zhu

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Caroline C Renner

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Clifford H Watson

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Connie S Sosnoff

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Dorothy K Hatsukami

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Irina Stepanov

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Matthew J Binnington

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Neal L Benowitz

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Rachel F Tyndale

http://www.w3.org/2001/XMLSchema#string

P2860

Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Tobacco carcinogens, their biomarkers and tobacco-induced cancer.

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

Urine menthol as a biomarker of mentholated cigarette smoking.

Comparison of urine cotinine and the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and their ratio to discriminate active from passive smoking

Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry

Racial differences in the relationship between number of cigarettes smoked and nicotine and carcinogen exposure.

Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk

Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers.

Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

P304

93-101

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10.1093/CARCIN/BGS306

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English

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Anne P. Lanier

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2012-10-01T00:00:00Z

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231742259

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23027621

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Alaska

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3534190

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Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.

about

P2860

P2860

Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.

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