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Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

http://www.wikidata.org/entity/Q36500996

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Quantifying the adaptive potential of an antibiotic resistance enzyme Replaying the tape of life in the twenty-first century The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids Elucidating the molecular architecture of adaptation via evolve and resequence experiments Spatiotemporal microbial evolution on antibiotic landscapes Evolutionary rescue: linking theory for conservation and medicine Microscale insights into pneumococcal antibiotic mutant selection windows Within-host evolution of bacterial pathogens.Antibiotic resistance in the wild: an eco-evolutionary perspective In vivo continuous directed evolution Coordinated Evolution of Influenza A Surface Proteins Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections Tackling Drug Resistant Infection Outbreaks of Global Pandemic Escherichia coli ST131 Using Evolutionary and Epidemiological Genomics.Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.Bacterial growth and adaptation in microdroplet chemostats.Origin of robustness in generating drug-resistant malaria parasites Within-Host Evolution of Burkholderia pseudomallei during Chronic Infection of Seven Australasian Cystic Fibrosis Patients.A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD+/NADH+ imbalance.Adaptive Laboratory Evolution of Antibiotic Resistance Using Different Selection Regimes Lead to Similar Phenotypes and Genotypes.Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB.Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro Causes of molecular convergence and parallelism in protein evolution.Genomics of rapid adaptation to antibiotics: convergent evolution and scalable sequence amplification Multidrug evolutionary strategies to reverse antibiotic resistance.Whole-genome sequencing to control antimicrobial resistance Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase.Antibiotics and the gut microbiota.Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance Prediction of antibiotic resistance by gene expression profiles.Systems mapping of HIV-1 infection.The effect of bacterial recombination on adaptation on fitness landscapes with limited peak accessibility Replaying the tape of life: quantification of the predictability of evolution.The evolutionary history of amino acid variations mediating increased resistance of S. aureus identifies reversion mutations in metabolic regulators Evolution after introduction of a novel metabolic pathway consistently leads to restoration of wild-type physiology.Genomic analysis reveals distinct concentration-dependent evolutionary trajectories for antibiotic resistance in Escherichia coli.Mutations in global regulators lead to metabolic selection during adaptation to complex environments.Insights into mechanisms and proteomic characterisation of Pseudomonas aeruginosa adaptation to a novel antimicrobial substance GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria.A low cost, customizable turbidostat for use in synthetic circuit characterization.

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P2860

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

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Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

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Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

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Nature Genetics

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Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

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Adrian Veres

http://www.w3.org/2001/XMLSchema#string

Daniel L Hartl

http://www.w3.org/2001/XMLSchema#string

Erdal Toprak

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Jean-Baptiste Michel

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Roy Kishony

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P2860

Genome evolution and adaptation in a long-term experiment with Escherichia coli

Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli

Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance

Bacterial charity work leads to population-wide resistance

The Sequence Alignment/Map format and SAMtools

Development of a novel continuous culture device for experimental evolution of bacterial populations

Structure, dynamics, and catalytic function of dihydrofolate reductase

Genetic architecture of intrinsic antibiotic susceptibility

Determinants of protein function revealed by combinatorial entropy optimization

Microbial Selection

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10.1038/NG.1034

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