Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice
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Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acidsTumor antigen epitopes interpreted by the immune system as self or abnormal-self differentially affect cancer vaccine responses.Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response.Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses.Tumor-infiltrating neutrophils in pancreatic neoplasia.MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.Design and synthesis of multifunctional gold nanoparticles bearing tumor-associated glycopeptide antigens as potential cancer vaccinesAntigen choice determines vaccine-induced generation of immunogenic versus tolerogenic dendritic cells that are marked by differential expression of pancreatic enzymes.Synthesis and immunological evaluation of a MUC1 glycopeptide incorporated into l-rhamnose displaying liposomes.Synthesis of a Liposomal MUC1 Glycopeptide-Based Immunotherapeutic and Evaluation of the Effect of l-Rhamnose Targeting on Cellular Immune ResponsesImmunobiology of human mucin 1 in a preclinical ovarian tumor model.MUC1-based recombinant Bacillus Calmette-Guerin vaccines as candidates for breast cancer immunotherapy.MUC1 immunotherapy.Colorectal cancer vaccines in clinical trials.The sweet side of tumor immunotherapy.MUC1-specific cytotoxic T lymphocytes in cancer therapy: induction and challenge.A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination.Human Tumor Antigens Yesterday, Today, and Tomorrow.Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.Myeloid glycosylation defects lead to a spontaneous common variable immunodeficiency-like condition with associated hemolytic anemia and antilymphocyte autoimmunity.Tn-MUC1 DC Vaccination of Rhesus Macaques and a Phase I/II Trial in Patients with Nonmetastatic Castrate-Resistant Prostate Cancer.Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice.Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen.Immunization with a Synthetic Human MUC1 Glycopeptide Vaccine against Tumor-Associated MUC1 Breaks Tolerance in Human MUC1 Transgenic Mice.Latest developments in MUC1 immunotherapy.
P2860
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P2860
Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Tumor-associated MUC1 glycopep ...... itopes in MUC1 transgenic mice
@ast
Tumor-associated MUC1 glycopep ...... itopes in MUC1 transgenic mice
@en
type
label
Tumor-associated MUC1 glycopep ...... itopes in MUC1 transgenic mice
@ast
Tumor-associated MUC1 glycopep ...... itopes in MUC1 transgenic mice
@en
prefLabel
Tumor-associated MUC1 glycopep ...... itopes in MUC1 transgenic mice
@ast
Tumor-associated MUC1 glycopep ...... itopes in MUC1 transgenic mice
@en
P2093
P2860
P356
P1433
P1476
Tumor-associated MUC1 glycopep ...... itopes in MUC1 transgenic mice
@en
P2093
Anda M Vlad
Jean Gariépy
Kazi Islam
Olivera J Finn
Sean O Ryan
P2860
P304
P356
10.1515/BC.2009.070
P577
2009-07-01T00:00:00Z