Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.
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Cytoprotective-selective activated protein C therapy for ischaemic strokeInflammation in Chronic WoundsProteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connectionRNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammationDifferential signaling by protease-activated receptors: implications for therapeutic targeting.Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteersThe role of EPCR in the pathogenesis of severe malariaFactor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.Endothelial cell protein C receptor: a multiliganded and multifunctional receptorNoncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity.Streptococcal SpeB cleaved PAR-1 suppresses ERK phosphorylation and blunts thrombin-induced platelet aggregation.Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular PatternsActivated protein C: biased for translation.Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro.Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 UbiquitinationProtease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury.Diverse functional outcomes of Plasmodium falciparum ligation of EPCR: potential implications for malarial pathogenesis.Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier StabilizationActivated protein C promotes neuroprotection: mechanisms and translation to the clinic.Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3.Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.Protease-activated receptors in hemostasis.Cofactoring and dimerization of proteinase-activated receptorsThrombin Generation and Atherothrombosis: What Does the Evidence Indicate?Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice.Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impactActivated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.Down-regulation of the clotting cascade by the protein C pathwayBiased signaling of protease-activated receptors.Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells.Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors.Protease-activated Receptor 1 Plays a Proinflammatory Role in Colitis by Promoting Th17-related Immunity.Proteinases, Their Extracellular Targets, and Inflammatory Signaling.2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).
P2860
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P2860
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Biased agonism of protease-act ...... oncanonical cleavage at Arg46.
@ast
Biased agonism of protease-act ...... oncanonical cleavage at Arg46.
@en
type
label
Biased agonism of protease-act ...... oncanonical cleavage at Arg46.
@ast
Biased agonism of protease-act ...... oncanonical cleavage at Arg46.
@en
prefLabel
Biased agonism of protease-act ...... oncanonical cleavage at Arg46.
@ast
Biased agonism of protease-act ...... oncanonical cleavage at Arg46.
@en
P2093
P2860
P1433
P1476
Biased agonism of protease-act ...... oncanonical cleavage at Arg46.
@en
P2093
Eveline A Bouwens
John H Griffin
Laurent O Mosnier
Ranjeet K Sinha
P2860
P304
P356
10.1182/BLOOD-2012-08-452169
P407
P577
2012-11-13T00:00:00Z