The antiapoptotic role of pregnane X receptor in human colon cancer cells.
about
Bile acids as endogenous etiologic agents in gastrointestinal cancerCross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implicationsRole of pregnane X receptor in chemotherapeutic treatmentTargeting xenobiotic receptors PXR and CAR in human diseasesPXR variants: the impact on drug metabolism and therapeutic responsesChallenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXRRole of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer ProgressionActivation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cellsThe protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells.Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Overcoming drug resistance by regulating nuclear receptors.Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.Tissue-specific regulation of pregnane X receptor in cancer development and therapy.Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancerPregnane X receptor- and CYP3A4-humanized mouse models and their applications.Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoPregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells.Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Expression of the PXR gene in various types of cancer and drug resistanceInterplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer.PXR interaction with p53: a meeting of two mastersHuman pregnane X receptor compromises the function of p53 and promotes malignant transformationPregnane X Receptor and Cancer: Context-Specificity is Key.A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.Orphan nuclear receptors as targets for drug development.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.PXR cross-talks with internal and external signals in physiological and pathophysiological responses.Pharmacogenetics of the nuclear hormone receptors: the missing link between environment and drug effects?Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery.Human Xenobiotic Nuclear Receptor PXR Augments Mycobacterium tuberculosis Survival.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.
P2860
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P2860
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
@ast
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
@en
type
label
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
@ast
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
@en
prefLabel
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
@ast
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
@en
P2093
P2860
P356
P1476
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
@en
P2093
Mingjie Liu
Yonggong Zhai
P2860
P304
P356
10.1210/ME.2007-0197
P577
2007-12-20T00:00:00Z