α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief.
about
15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuseMolecular mechanisms underlying behaviors related to nicotine addictionGenetic matters: thirty years of progress using mouse models in nicotinic research.Molecules and circuits involved in nicotine addiction: The many faces of smokingPreclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotypeCognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial PerspectiveAcute nicotine induces anxiety and disrupts temporal pattern organization of rat exploratory behavior in hole-board: a potential role for the lateral habenulaAttenuation of Compulsive-Like Behavior Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Non-Induced Compulsive-Like MiceLow dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in micenAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives.Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders.Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memoriesHow cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways.Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse.Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior.Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells.Discriminative stimulus and hypothermic effects of some derivatives of the nAChR agonist epibatidine in miceThe α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental areaAnxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptorsDifferential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral statesNicotinic receptor contributions to smoking: insights from human studies and animal modelsEffects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and miceAnxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP).Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density.Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependenceUnraveling the neurobiology of nicotine dependence using genetically engineered miceInjectable, cellular-scale optoelectronics with applications for wireless optogenetics.Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule.A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability.Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependenceRare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors.Utility of genetically modified mice for understanding the neurobiology of substance use disorders.Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function α6* nAChRs.Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brainAllosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery.Possible contributions of a novel form of synaptic plasticity in Aplysia to reward, memory, and their dysfunctions in mammalian brain.Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation.Nicotine Addiction and Psychiatric Disorders.Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.
P2860
Q26824667-79396A95-46FD-46E2-9AD3-16B5E7F7EEBFQ26851972-FEF40E13-5D0F-491A-8ABD-83CB61EC250EQ26853457-E5D398C8-D7DC-44C9-AA04-6383AE043AE2Q27008063-6D7594B8-1566-4514-B7D2-1CEBB7527513Q27021772-4D6388E3-BB1F-4944-9DAC-AB3D7A735772Q28071876-FF1E6313-CB08-4BC9-B3E2-A229673CB80FQ28263613-2C0C3D71-D7F6-4A60-A7D9-80F8481A3973Q28468423-B19CECB4-E535-4C10-BF63-5B80BFD93AE1Q28484969-528A3ED8-1043-4B63-9946-F74DC64BF172Q30362464-BBF8B94D-E01D-4B08-8458-135871BF70D3Q30372354-DA0F8ACE-4454-4188-91A9-E48FDED86EEFQ30391283-765D5A06-5DAC-4BB1-BBBE-2C464D5736B8Q30453328-FF2B7AED-9946-4322-A848-51CE78DA42C7Q33859960-DE0FA9CA-E815-463D-8AF1-990F42D85438Q34304101-CC240C49-F707-4F77-ADDC-51BEB038E20FQ34392757-56FCC325-A895-4532-A790-2C2F2B623B62Q34474014-91A27682-AA1A-4225-9584-DA08679A5BD7Q34837643-729C96F8-A115-40ED-86A6-9207D06D5516Q35631485-BC9E999A-6ADE-49AA-B69F-5EF5B9D523A2Q35647302-0BB324FA-6E7D-4E41-BB13-219673BC7A48Q35802079-212C63AB-8A2E-4999-BC4A-2E2B653D8386Q35966896-EE152C94-0AF3-4282-99F4-F11BFB403AC5Q36298187-53CE5A34-D39B-4CA7-B7DC-BE67F2ACF430Q36378201-2860C2B6-6B11-4170-A7E2-F36504456E54Q36927768-AB48A02F-A69C-47F9-84D0-75CD2422387BQ37058633-74B91EE9-14B9-4F6B-86F2-C45591791F13Q37076206-E731EA0E-771C-4DF4-BFBE-FCE2633842F1Q37162596-309944DC-0B4E-4472-8D01-E9C0B5158D7CQ37252061-2C82100F-C3A2-4E2A-8217-135A0C3B6AC9Q37365090-38F9FF47-6878-45FF-A468-76B2FC99934CQ37463998-5C88D5C1-4558-41DE-8A1E-1924E48F4A13Q37603902-529C7DCC-02ED-41AA-B85A-EB4241F15B10Q37687946-2C65F1AD-4EC0-4A31-AC3E-B1B79E08AA71Q37692812-95FCB7EA-DBE3-4A97-8D45-6B91621E1AF2Q37722609-24948D13-678B-4E6F-9E81-8B4B5930AF13Q38063303-D8E9943F-2BBE-44D3-B8AE-6398C02106F5Q38139358-3012F78C-CBD9-4067-8CAD-F245E18BBB94Q38204497-8D7C6AA3-C955-48D9-A696-B5A87C70FEB3Q38608639-C48E3873-2D12-40C4-BABF-544ADDAF73BFQ40101234-826104D6-0CC6-4B09-A9E7-5AF2F398FB6D
P2860
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
α4β2 nicotinic acetylcholine r ...... ine reward and anxiety relief.
@ast
α4β2 nicotinic acetylcholine r ...... ine reward and anxiety relief.
@en
type
label
α4β2 nicotinic acetylcholine r ...... ine reward and anxiety relief.
@ast
α4β2 nicotinic acetylcholine r ...... ine reward and anxiety relief.
@en
prefLabel
α4β2 nicotinic acetylcholine r ...... ine reward and anxiety relief.
@ast
α4β2 nicotinic acetylcholine r ...... ine reward and anxiety relief.
@en
P2093
P2860
P1476
α4β2 nicotinic acetylcholine r ...... ine reward and anxiety relief.
@en
P2093
Natalie E Patzlaff
Sharon R Grady
Stephen F Heinemann
T K Booker
Tresa M McGranahan
P2860
P304
10891-10902
P356
10.1523/JNEUROSCI.0937-11.2011
P407
P577
2011-07-01T00:00:00Z