Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.
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pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC)Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degenerationModulation of deregulated chaperone-mediated autophagy by a phosphopeptideFunctional roles of bestrophins in ocular epitheliaAutophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationNorbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In VivoLoss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patientsInhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell.Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMPPharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.Autophagy in the eye: implications for ocular cell health.Identification of genetic variation and haplotype structure of the canine ABCA4 gene for retinal disease association studiesPurines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases.Light filtering in a retinal pigment epithelial cell culture model.The role of Bcl-xL in mouse RPE cell survival.SERS nanosensors that report pH of endocytic compartments during FcεRI transitProtein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and AnoikisLive Cells as Dynamic Laboratories: Time Lapse Raman Spectral Microscopy of Nanoparticles with Both IgE Targeting and pH-Sensing Functions.Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying MechanismsProtecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress.Mechanisms for countering oxidative stress and damage in retinal pigment epithelium.Medical bioremediation of age-related diseases.Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor.Soluble adenylyl cyclase is essential for proper lysosomal acidificationDry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers.Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells.Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells.Autophagy in the retina: a potential role in age-related macular degeneration.Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells.Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations.Phagocytosis-dependent ketogenesis in retinal pigment epithelium.Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.Chemical screening identifies ATM as a target for alleviating senescence.Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases.Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.First-Generation Antipsychotic Haloperidol Alters the Functionality of the Late Endosomal/Lysosomal Compartment in Vitro
P2860
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P2860
Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Restoration of lysosomal pH in ...... aches and functional recovery.
@ast
Restoration of lysosomal pH in ...... aches and functional recovery.
@en
type
label
Restoration of lysosomal pH in ...... aches and functional recovery.
@ast
Restoration of lysosomal pH in ...... aches and functional recovery.
@en
prefLabel
Restoration of lysosomal pH in ...... aches and functional recovery.
@ast
Restoration of lysosomal pH in ...... aches and functional recovery.
@en
P2093
P2860
P356
P1476
Restoration of lysosomal pH in ...... aches and functional recovery.
@en
P2093
Alan M Laties
Claire H Mitchell
David Reigada
Jonathan Nguyen
P2860
P304
P356
10.1167/IOVS.07-0675
P407
P577
2008-02-01T00:00:00Z