Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
about
Cholesterol homeostasis: a key to prevent or slow down neurodegenerationApolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapyAmyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretionLocalization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.Autoinsertion of soluble oligomers of Alzheimer's Abeta(1-42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface.Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of diseaseCross-talk of membrane lipids and Alzheimer-related proteins.The effects of cholesterol on learning and memory.Gene-based testing of interactions in association studies of quantitative traitsLTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic deliveryApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons.Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?Apolipoprotein E and cholesterol in aging and disease in the brainGene therapy in Alzheimer's disease - potential for disease modificationMembrane and surface interactions of Alzheimer's Aβ peptide--insights into the mechanism of cytotoxicity.Studying the role of ApoE in Alzheimer's disease pathogenesis using a systems biology model.Dietary intake of plant sterols stably increases plant sterol levels in the murine brain.Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.
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P2860
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
description
2006 nî lūn-bûn
@nan
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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2006年论文
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2006年论文
@zh-cn
name
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
@ast
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
@en
type
label
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
@ast
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
@en
prefLabel
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
@ast
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
@en
P2860
P1433
P1476
Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
@en
P2093
Carlos G Dotti
Maria Dolores Ledesma
P2860
P304
P356
10.1016/J.FEBSLET.2006.06.038
P407
P577
2006-06-23T00:00:00Z