Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes
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Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesTargeting the sarcomere to correct muscle functionPerturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsAAV-mediated gene therapy for heart failure: enhancing contractility and calcium handlingLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationSmall and large animal models in cardiac contraction research: advantages and disadvantagesA novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysisGenotype-specific pathogenic effects in human dilated cardiomyopathy.Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.Troponin I phosphorylation in human myocardium in health and disease.Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulationsRemoval of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle.Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.Pathomechanisms in heart failure: the contractile connection.Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres.Cardiac troponin I phosphorylation and the force-length relationship.Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy.Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo.The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform.First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos.Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24.Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy.Monophosphorylation of cardiac troponin-I at Ser23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis.
P2860
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P2860
Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Impact of site-specific phosph ...... onin I in human cardiomyocytes
@ast
Impact of site-specific phosph ...... onin I in human cardiomyocytes
@en
type
label
Impact of site-specific phosph ...... onin I in human cardiomyocytes
@ast
Impact of site-specific phosph ...... onin I in human cardiomyocytes
@en
prefLabel
Impact of site-specific phosph ...... onin I in human cardiomyocytes
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Impact of site-specific phosph ...... onin I in human cardiomyocytes
@en
P2093
P2860
P1476
Impact of site-specific phosph ...... onin I in human cardiomyocytes
@en
P2093
Aisha H Frazier
Allison L Tsao
Anne M Murphy
Cristobal G dos Remedios
D Brian Foster
Ger J M Stienen
Paul J M Wijnker
P2860
P304
P356
10.1152/AJPHEART.00498.2012
P577
2012-11-09T00:00:00Z