Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
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Direct inhibition of the NOTCH transcription factor complexStem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel SyndromeTargeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Cellular Response upon Stress: p57 Contribution to the Final OutcomeNotch signaling deregulation in multiple myeloma: A rational molecular targetAdult mammalian stem cells: the role of Wnt, Lgr5 and R-spondinsDefining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathwaysModelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal cryptNOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?Epigenetic regulation of the intestinal epitheliumNotch signaling in stomach epithelial stem cell homeostasisDelta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell systemThe extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney developmentDll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cellsThe transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocationNOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive nichesHes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland developmentNotch lineages and activity in intestinal stem cells determined by a new set of knock-in miceGene-expression analysis of hair cell regeneration in the zebrafish lateral line.Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endotheliaCharacterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cellsNotch as a Driver of Gastric Epithelial Cell Proliferation.Notch: architect, landscaper, and guardian of the intestine.In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafishmicroRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancerLoss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival.FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitroThe Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cellsMouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fateComplex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis.GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature miceIntestinal development and differentiation.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Notch signaling in pediatric soft tissue sarcomasTargeting Notch Signaling in Colorectal Cancer.FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study
P2860
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P2860
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Loss of intestinal crypt proge ...... nhibitors p27Kip1 and p57Kip2.
@ast
Loss of intestinal crypt proge ...... nhibitors p27Kip1 and p57Kip2.
@en
type
label
Loss of intestinal crypt proge ...... nhibitors p27Kip1 and p57Kip2.
@ast
Loss of intestinal crypt proge ...... nhibitors p27Kip1 and p57Kip2.
@en
prefLabel
Loss of intestinal crypt proge ...... nhibitors p27Kip1 and p57Kip2.
@ast
Loss of intestinal crypt proge ...... nhibitors p27Kip1 and p57Kip2.
@en
P2093
P2860
P50
P356
P1433
P1476
Loss of intestinal crypt proge ...... nhibitors p27Kip1 and p57Kip2.
@en
P2093
April C Bezdek
Hans Clevers
Johan H van Es
Lothar J Strobl
Marielle E van Gijn
Orbicia Riccio
Ursula Zimber-Strobl
P2860
P304
P356
10.1038/EMBOR.2008.7
P577
2008-02-15T00:00:00Z