The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
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Subversion of cytokine networks by virally encoded decoy receptorsEvidence for Persistence of Ectromelia Virus in Inbred Mice, Recrudescence Following Immunosuppression and Transmission to Naïve MiceSide-by-side comparison of gene-based smallpox vaccine with MVA in nonhuman primatesStructural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding proteinSequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus InfectionThe mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy.Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.A method for the generation of ectromelia virus (ECTV) recombinants: in vivo analysis of ECTV vCD30 deletion mutants.New classes of orthopoxvirus vaccine candidates by functionally screening a synthetic library for protective antigens.A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus.Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responsesThe genome sequence of ectromelia virus Naval and Cornell isolates from outbreaks in North America.Elucidating the role of the complement control protein in monkeypox pathogenicityAge-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and traffickingEvaluating the orthopoxvirus type I interferon-binding molecule as a vaccine target in the vaccinia virus intranasal murine challenge model.TLR3 and TLR9 agonists improve postexposure vaccination efficacy of live smallpox vaccines.Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections.Vaccine-induced protection against orthopoxvirus infection is mediated through the combined functions of CD4 T cell-dependent antibody and CD8 T cell responses.CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization.Glycosaminoglycans mediate retention of the poxvirus type I interferon binding protein at the cell surface to locally block interferon antiviral responses.Polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease.The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responsesLoss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo.Monkeypox virus and insights into its immunomodulatory proteins.Molecular smallpox vaccine delivered by alphavirus replicons elicits protective immunity in mice and non-human primates.Infection with diverse immune-modulating poxviruses elicits different compositional shifts in the mouse gut microbiomeThe strategic use of novel smallpox vaccines in the post-eradication world.Ectromelia virus accumulates less double-stranded RNA compared to vaccinia virus in BS-C-1 cells.RNA-Seq Based Transcriptome Analysis of the Type I Interferon Host Response upon Vaccinia Virus Infection of Mouse CellsThe highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon.Postexposure immunization with modified vaccinia virus Ankara or conventional Lister vaccine provides solid protection in a murine model of human smallpox.Memory CD8⁺ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection.Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection.Tricked or trapped-Two decoy mechanisms in host-pathogen interactions.Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox.Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation.New insights into the immunomodulatory properties of poxvirus cytokine decoy receptors at the cell surface.The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus.
P2860
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P2860
The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The orthopoxvirus type I IFN b ...... fective target for vaccination
@ast
The orthopoxvirus type I IFN b ...... fective target for vaccination
@en
type
label
The orthopoxvirus type I IFN b ...... fective target for vaccination
@ast
The orthopoxvirus type I IFN b ...... fective target for vaccination
@en
prefLabel
The orthopoxvirus type I IFN b ...... fective target for vaccination
@ast
The orthopoxvirus type I IFN b ...... fective target for vaccination
@en
P2093
P2860
P356
P1476
The orthopoxvirus type I IFN b ...... fective target for vaccination
@en
P2093
Eric Lazear
Gary H Cohen
J Charles Whitbeck
Luis J Sigal
Matthew Cohen
Ren-Huan Xu
P2860
P304
P356
10.1084/JEM.20071854
P407
P577
2008-04-07T00:00:00Z