Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.
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Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse. Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in hGenetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicologyDevelopment and progress for three decades in umu test systemsHeterologous expression, purification and characterization of rat class theta glutathione transferase T2-2Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variantsIncreased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1Contributions of human enzymes in carcinogen metabolismDNA polymerase I is essential for growth of Methylobacterium dichloromethanicum DM4 with dichloromethaneCarcinogenicity and genotoxicity of ethylene oxide: new aspects and recent advances.Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: an update and practical considerations.Dehalogenation of dichloromethane by dichloromethane dehalogenase/glutathione S-transferase leads to formation of DNA adducts.What's in the pool? A comprehensive identification of disinfection by-products and assessment of mutagenicity of chlorinated and brominated swimming pool waterBacterial glutathione S-transferases: what are they good for?The role of individual susceptibility in cancer burden related to environmental exposure.Human health effects of dichloromethane: key findings and scientific issuesInsights from epidemiology into dichloromethane and cancer risk.Glutathione-dependent bioactivation of haloalkanes and haloalkenes.Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in RatsLife and times in biochemical toxicology.DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system.The use of glutathione transferase-knockout mice as pharmacological and toxicological models.Integrated disinfection by-products research: salmonella mutagenicity of water concentrates disinfected by chlorination and ozonation/postchlorination.In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.On enzyme-based anticancer molecular dietary manipulations.A molecular genetic approach for the identification of essential residues in human glutathione S-transferase function in Escherichia coli.Advanced Approaches to Model Xenobiotic Metabolism in Bacterial Genotoxicology In Vitro.New applications of bacterial systems to problems in toxicology.Methylene chloride induced mouse liver and lung tumours: an overview of the role of mechanistic studies in human safety assessment.Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates.Analysis of the cytotoxicity and mutagenicity of drinking water disinfection by-products in Salmonella typhimurium.Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells.Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.Purification and characterization of a recombinant human Theta-class glutathione transferase (GSTT2-2).Bacterial Community Dynamics in Dichloromethane-Contaminated Groundwater Undergoing Natural Attenuation.Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo[a]pyrene.Disposition of bromodichloromethane in humans following oral and dermal exposure.
P2860
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P2860
Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Expression of mammalian glutat ...... on exposure to dihalomethanes.
@ast
Expression of mammalian glutat ...... on exposure to dihalomethanes.
@en
type
label
Expression of mammalian glutat ...... on exposure to dihalomethanes.
@ast
Expression of mammalian glutat ...... on exposure to dihalomethanes.
@en
prefLabel
Expression of mammalian glutat ...... on exposure to dihalomethanes.
@ast
Expression of mammalian glutat ...... on exposure to dihalomethanes.
@en
P2093
P2860
P356
P1476
Expression of mammalian glutat ...... on exposure to dihalomethanes.
@en
P2093
B Ketterer
F P Guengerich
J B Taylor
M Persmark
S E Pemble
W G Humphreys
P2860
P304
P356
10.1073/PNAS.90.18.8576
P407
P577
1993-09-01T00:00:00Z