Current views on the fundamental mechanisms of cytochrome P450 allosterism.
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A novel type of allosteric regulation: functional cooperativity in monomeric proteinsAllosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicityDefining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450.Analysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone.Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5.Understanding cooperativity in human p450 mediated drug-drug interactions.The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4Principal component analysis of CYP2C9 and CYP3A4 probe substrate/inhibitor panels.Substrate binding to cytochromes P450.In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions.Cooperative properties of cytochromes P450.Cooperative effects for CYP2E1 differ between styrene and its metabolites.Substrate inhibition kinetics in drug metabolism reactions.Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.Allosteric effects on substrate dissociation from cytochrome P450 3A4 in nanodiscs observed by ensemble and single-molecule fluorescence spectroscopy.Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.Activation of CYP3A-mediated testosterone 6β-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes.Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene.Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.
P2860
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P2860
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
description
2006 nî lūn-bûn
@nan
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
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2006年论文
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name
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
@ast
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
@en
type
label
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
@ast
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
@en
prefLabel
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
@ast
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
@en
P2860
P356
P1476
Current views on the fundamental mechanisms of cytochrome P450 allosterism.
@en
P2093
William M Atkins
P2860
P304
P356
10.1517/17425255.2.4.573
P407
P577
2006-08-01T00:00:00Z