CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.
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Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.CD70 is downregulated by interaction with CD27.Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiencySurrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.Therapeutic targeting of CD70 and CD27.Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.Tregs strip dendritic cells of CD70 to regulate Th1 differentiation.CD27 costimulation contributes substantially to the expansion of functional memory CD8(+) T cells after peptide immunization.CD70 encoded by modified vaccinia virus Ankara enhances CD8 T cell dependent protective immunity in MHC class II-deficient mice.Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications.T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.CD70 Deficiency due to a Novel Mutation in a Patient with Severe Chronic EBV Infection Presenting As a Periodic Fever.Unique features and clinical importance of acute alloreactive immune responses.
P2860
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P2860
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
CD70 deficiency impairs effect ...... ocytic choriomeningitis virus.
@ast
CD70 deficiency impairs effect ...... ocytic choriomeningitis virus.
@en
type
label
CD70 deficiency impairs effect ...... ocytic choriomeningitis virus.
@ast
CD70 deficiency impairs effect ...... ocytic choriomeningitis virus.
@en
prefLabel
CD70 deficiency impairs effect ...... ocytic choriomeningitis virus.
@ast
CD70 deficiency impairs effect ...... ocytic choriomeningitis virus.
@en
P2093
P2860
P356
P1476
CD70 deficiency impairs effect ...... hocytic choriomeningitis virus
@en
P2093
Atef Allam
Jonathan D Ashwell
Jonathan P Scoville
P2860
P304
P356
10.4049/JIMMUNOL.1202353
P407
P577
2012-12-26T00:00:00Z