Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases
about
Histone methyltransferases: novel targets for tumor and developmental defectsStructural origins for the product specificity of SET domain protein methyltransferasesSET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple MethylationInvestigation of the Molecular Origins of Protein-arginine Methyltransferase I (PRMT1) Product Specificity Reveals a Role for Two Conserved Methionine ResiduesCatalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1An alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase.Current limitations and future opportunities for epigenetic therapies.QM/MM MD and free energy simulations of G9a-like protein (GLP) and its mutants: understanding the factors that determine the product specificityEZH2: biology, disease, and structure-based drug discoveryCoordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex.Protein and nucleic acid methylating enzymes: mechanisms and regulationQM/MM MD and free energy simulation study of methyl transfer processes catalyzed by PKMTs and PRMTs.Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET.Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis.Acid-base chemistry of frustrated water at protein interfaces.Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives.SET7/9 inhibits oncogenic activities through regulation of Gli-1 expression in breast cancer.Catalytic Role of Dehydrons in Soluble Proteins: Biological Chemistry of Frustrated Interfacial Water
P2860
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P2860
Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Enzymatic mechanism and produc ...... tein lysine methyltransferases
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Enzymatic mechanism and produc ...... tein lysine methyltransferases
@en
type
label
Enzymatic mechanism and produc ...... tein lysine methyltransferases
@ast
Enzymatic mechanism and produc ...... tein lysine methyltransferases
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prefLabel
Enzymatic mechanism and produc ...... tein lysine methyltransferases
@ast
Enzymatic mechanism and produc ...... tein lysine methyltransferases
@en
P2860
P356
P1476
Enzymatic mechanism and produc ...... tein lysine methyltransferases
@en
P2093
Thomas C Bruice
Xiaodong Zhang
P2860
P304
P356
10.1073/PNAS.0801788105
P407
P577
2008-04-07T00:00:00Z