about
Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related DiseasesNuclear Receptors, RXR, and the Big BangPhospholipid--driven gene regulationModulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR in human diseasesSmall Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)A natural-product switch for a dynamic protein interfaceFragment Screening of RORγt Using Cocktail Crystallography: Identification of Simultaneous Binding of Multiple FragmentsPredicting drug-target interaction networks based on functional groups and biological featuresPotent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screeningFunctional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.Mechanism of androgen receptor antagonism by bicalutamide in the treatment of prostate cancerLigand and receptor dynamics contribute to the mechanism of graded PPARγ agonism.PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewalRifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins.The Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq.Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells.Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancerSynthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffoldsThe nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunityCellular stress response pathway system as a sentinel ensemble in toxicological screening.Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis.More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands.Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT.Modulation of nuclear receptor function by cellular redox poise.Nuclear receptor Rev-erbα: up, down, and all around.Structurally similar estradiol analogs uniquely alter the regulation of intracellular signaling pathways.An alternate binding site for PPARγ ligandsMultitarget Drugs: an Epigenetic Epiphany.Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning.Cell-specific integration of nuclear receptor function at the genome.Nuclear receptors in neural stem/progenitor cell homeostasis.Development of improved PPARβ/δ inhibitors.Transcriptional regulation of human and murine short-chain dehydrogenase/reductases (SDRs) - an in silico approach.Molecular mechanisms of transcriptional control by Rev-erbα: An energetic foundation for reconciling structure and binding with biological functionActivation helix orientation of the estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations.Exploring the molecular basis of action of ring D aromatic steroidal antiestrogens.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The nuclear receptor superfamily and drug discovery.
@ast
The nuclear receptor superfamily and drug discovery.
@en
type
label
The nuclear receptor superfamily and drug discovery.
@ast
The nuclear receptor superfamily and drug discovery.
@en
prefLabel
The nuclear receptor superfamily and drug discovery.
@ast
The nuclear receptor superfamily and drug discovery.
@en
P2093
P2860
P356
P1433
P1476
The nuclear receptor superfamily and drug discovery.
@en
P2093
John T Moore
Jon L Collins
Kenneth H Pearce
P2860
P304
P356
10.1002/CMDC.200600006
P577
2006-05-01T00:00:00Z