Cell transformation mediated by homodimeric E2A-HLF transcription factors.
about
The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLFDisrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic miceTwo distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogeneRole for homodimerization in growth deregulation by E2a fusion proteins.E2A-HLF usurps control of evolutionarily conserved survival pathways.Transcription factor RF2a alters expression of the rice tungro bacilliform virus promoter in transgenic tobacco plants.Attractive interhelical electrostatic interactions in the proline- and acidic-rich region (PAR) leucine zipper subfamily preclude heterodimerization with other basic leucine zipper subfamilies.Novel member of the PAR domain bZIP gene family isolated from Pacific oyster, Crassostrea gigas.Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1.Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity.Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.
P2860
Q24522770-1A3A6224-4B50-4F35-94EA-A80A8F0A63F1Q33652525-D9A02E59-4644-442F-987C-527C2D78BD9EQ33957711-A3974517-7EB2-424C-8393-07F236AFEBB5Q33964561-4E38A961-B3A9-475E-9439-38CB38D0EECDQ33964971-B2FFA7E1-7A1F-4FF1-BFE6-CE3A3E6E30ADQ34405477-7B2BEB6E-8A92-446D-9562-9D60DE4973E9Q36319394-4A47A20A-04D8-4FF4-9ED8-B6C296A73F41Q38309374-F4E0A36A-6470-4E83-A8C1-1C36C46CCCFBQ38335179-E6FF9338-A99C-4E7E-8740-AA90402F784DQ39323262-F57BBB04-12C0-4ABC-B92D-B708F5F2AE80Q39460862-63746CE8-9FB0-4237-814A-3883451037D0Q43970140-D27709E6-6910-4C10-88E0-3B6E180D36CFQ51918384-842DA6F4-96AB-45BB-AC17-992EEB7B43D0Q54566038-011D377A-F3E9-4DAE-AC3F-847D6176E9AD
P2860
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
@ast
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
@en
type
label
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
@ast
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
@en
prefLabel
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
@ast
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
@en
P2093
P2860
P356
P1476
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
@en
P2093
P2860
P304
P356
10.1128/MCB.17.3.1417
P407
P577
1997-03-01T00:00:00Z