The eag domain regulates hERG channel inactivation gating via a direct interaction.
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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channelCalmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology DomainAn Interdomain KCNH2 Mutation Produces an Intermediate Long QT SyndromeMolecular mechanism of voltage-dependent potentiation of KCNH potassium channelsConcerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channelsThe Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.hERG 1b is critical for human cardiac repolarizationC-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor.Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput ScreeningDirect interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domainUbiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.The enigmatic cytoplasmic regions of KCNH channels.Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer.Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome.Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells.Fluid flow modulates electrical activity in cardiac hERG potassium channels.Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.
P2860
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P2860
The eag domain regulates hERG channel inactivation gating via a direct interaction.
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2013 nî lūn-bûn
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2013年の論文
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name
The eag domain regulates hERG channel inactivation gating via a direct interaction.
@ast
The eag domain regulates hERG channel inactivation gating via a direct interaction.
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label
The eag domain regulates hERG channel inactivation gating via a direct interaction.
@ast
The eag domain regulates hERG channel inactivation gating via a direct interaction.
@en
prefLabel
The eag domain regulates hERG channel inactivation gating via a direct interaction.
@ast
The eag domain regulates hERG channel inactivation gating via a direct interaction.
@en
P2860
P356
P1476
The eag domain regulates hERG channel inactivation gating via a direct interaction.
@en
P2093
Ahleah S Gustina
Matthew C Trudeau
P2860
P304
P356
10.1085/JGP.201210870
P577
2013-01-14T00:00:00Z