Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes.
about
Recent advances in vaccine development for herpes simplex virus types I and IIConstruction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an HSV-1 virion host shutoff protein.A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.Prospects and perspectives for development of a vaccine against herpes simplex virus infections.Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 diseaseEvidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa.Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cellsHerpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease.Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex VaccineProtection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus.Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections.Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs.Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge.Genetic engineering of a modified herpes simplex virus 1 vaccine vector.Generating protective immunity against genital herpesSingle dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responsesWorldwide circulation of HSV-2 × HSV-1 recombinant strains.HSV Recombinant Vectors for Gene Therapy.Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls.Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains.
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P2860
Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Disruption of the U(L)41 gene ...... urine model of genital herpes.
@ast
Disruption of the U(L)41 gene ...... urine model of genital herpes.
@en
type
label
Disruption of the U(L)41 gene ...... urine model of genital herpes.
@ast
Disruption of the U(L)41 gene ...... urine model of genital herpes.
@en
prefLabel
Disruption of the U(L)41 gene ...... urine model of genital herpes.
@ast
Disruption of the U(L)41 gene ...... urine model of genital herpes.
@en
P2093
P2860
P1433
P1476
Disruption of the U(L)41 gene ...... urine model of genital herpes.
@en
P2093
David M Knipe
Lydia C Mathews
Timothy Dudek
P2860
P304
P356
10.1016/J.VIROL.2007.10.014
P407
P577
2007-11-19T00:00:00Z