TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma. - Wikidata - wikimedia - TriplyDB

TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma.

TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma.

http://www.wikidata.org/entity/Q36586540

about

Human but not mouse adipogenesis is critically dependent on LMO3 Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.P65 inactivation in adipocytes and macrophages attenuates adipose inflammatory response in lean but not in obese mice.Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders.TNF-related apoptosis-inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation.A major role of insulin in promoting obesity-associated adipose tissue inflammation.An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma.TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors.TWEAK: A New Player in Obesity and Diabetes.TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes.Low Circulating TRAIL Levels Are Associated with Increase of Resistin and Lipocalin-2/ngal Adipokines in Postmenopausal Women.The levels of circulating TRAIL at the onset of type 1 diabetes are markedly decreased in patients with ketoacidosis and with the highest insulin requirement.Lentivirus-mediated angiopoietin-2 gene silencing decreases TNF-α induced apoptosis of alveolar epithelium cells.TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.Caspases in metabolic disease and their therapeutic potential.Developing TRAIL/TRAIL death receptor-based cancer therapies.

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TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma.

http://www.wikidata.org/entity/Q36586540

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2013 nî lūn-bûn

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TRAIL (TNF-related apoptosis-i ...... ediated cleavage of PPARgamma.

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Cell Death and Disease

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TRAIL (TNF-related apoptosis-i ...... ediated cleavage of PPARgamma.

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G Strauss

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I Wernstedt Asterholm

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K-M Debatin

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M Keuper

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M-A Westhoff

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P Möller

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P2860

Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis

Identification and characterization of a new member of the TNF family that induces apoptosis

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Obesity is associated with macrophage accumulation in adipose tissue

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types

Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice.

Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors.

The role of TNFalpha and TNF receptors in obesity and insulin resistance.

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10.1038/CDDIS.2012.212

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4

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Martin Wabitsch

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235370985

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