Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.
about
NO* binds human cystathionine β-synthase quickly and tightlyMolecular mechanisms of disease-causing missense mutationsProtein homeostasis disorders of key enzymes of amino acids metabolism: mutation-induced protein kinetic destabilization and new therapeutic strategies.S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase.Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine β-Synthase.Kinetics of reversible reductive carbonylation of heme in human cystathionine β-synthase.A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?Innovative strategies to treat protein misfolding in inborn errors of metabolism: pharmacological chaperones and proteostasis regulators.Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.Chemical Biology of H2S Signaling through Persulfidation.The c.797 G>A (p.R266K) cystathionine β-synthase mutation causes homocystinuria by affecting protein stability.Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate.
P2860
Q24336765-A9DF72DF-B487-4809-95FE-64B482767019Q27021940-5DFEBC2D-9C00-4ED2-8ADD-A3707341642BQ30355120-7CD7090F-071A-4741-AA50-B8FE21ABB676Q36442325-AABD3D4A-30C0-4000-8142-616F53671E25Q36778803-10175955-DEFD-4A28-B509-A32071C8EB2DQ37089366-7166420B-2E2F-4BC4-85A5-936219EFB0CDQ37738145-BCDEEBDA-F45A-462E-8AD4-851D123DE1F9Q38200933-B0A43EED-F79C-4695-8496-F9088D109AB1Q45730250-0E25ECB3-7067-4A8D-9854-6ADCAAC06F05Q47430972-A1875AF5-4BC1-485D-8D79-CD1F3C7000CAQ48166084-9B209820-31E7-482A-B6C4-0C572FC682FAQ51746265-AAD1231F-7F33-4982-9832-ECD183D46E5E
P2860
Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Effect of the disease-causing ...... uman cystathionine β-synthase.
@ast
Effect of the disease-causing ...... uman cystathionine β-synthase.
@en
type
label
Effect of the disease-causing ...... uman cystathionine β-synthase.
@ast
Effect of the disease-causing ...... uman cystathionine β-synthase.
@en
prefLabel
Effect of the disease-causing ...... uman cystathionine β-synthase.
@ast
Effect of the disease-causing ...... uman cystathionine β-synthase.
@en
P2093
P2860
P356
P1433
P1476
Effect of the disease-causing ...... uman cystathionine β-synthase.
@en
P2093
Aaron T Smith
Daniel J Stevens
Jan P Kraus
Judith N Burstyn
P2860
P304
P356
10.1021/BI300421Z
P407
P50
P577
2012-07-31T00:00:00Z