Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. - Wikidata - wikimedia - TriplyDB

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood.

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood.

http://www.wikidata.org/entity/Q36602220

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Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss.High-throughput sequencing of immune repertoires in multiple sclerosis Involvement of CD8(+) T Cells in Multiple Sclerosis Neurobehavioral burden of multiple sclerosis with nanotheranostics The immunomodulatory and neuroprotective effects of mesenchymal stem cells (MSCs) in experimental autoimmune encephalomyelitis (EAE): a model of multiple sclerosis (MS)CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis Is Multiple Sclerosis an Autoimmune Disease?Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases Multiple Sclerosis and T Lymphocytes: An Entangled Story Analysis of the paired TCR α- and β-chains of single human T cells Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease.A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data?Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues.A translatable molecular approach to determining CD8 T-cell epitopes in TMEV infection Degenerate T-cell receptor recognition, autoreactive cells, and the autoimmune response in multiple sclerosis.Individual characterization of stably expanded T cell clones in ankylosing spondylitis patients.Novel approaches for identifying target antigens of autoreactive human B and T cells Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice.Predominant clonal accumulation of CD8+ T cells with moderate avidity in the central nervous systems of Theiler's virus-infected C57BL/6 mice.Antiviral immune responses: triggers of or triggered by autoimmunity?The use of natalizumab for multiple sclerosis Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis.Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function.The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes.The immunological basis for treatment of multiple sclerosis.Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis.Axonal damage in multiple sclerosis.The double-edged sword of autoimmunity: lessons from multiple sclerosis.High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells.αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis.Immunologic factors in primary progressive multiple sclerosis.Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis.VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires.Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity.Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines.

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Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood.

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Multiple sclerosis: brain-infi ...... cerebrospinal fluid and blood.

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Axel Roers

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Christian Skulina

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Hartmut Wekerle

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Holger Babbe

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Klaus Dornmair

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Reinhard Hohlfeld

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Stephan Schmidt

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P2860

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis

Probing degeneracy in T-cell recognition using peptide combinatorial libraries.

Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy.

Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis.

An integrative model of regulation centered on recognition of TCR peptide/MHC complexes.

Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases.

Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.

The blood-brain barrier and its role in immune privilege in the central nervous system.

Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis

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