Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
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Correlation of cell-free DNA plasma concentration with severity of non-alcoholic fatty liver disease.Pro-Inflammatory Cytokines but Not Endotoxin-Related Parameters Associate with Disease Severity in Patients with NAFLDIn Silico Identification of Proteins Associated with Drug-induced Liver Injury Based on the Prediction of Drug-target Interactions.Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicityDysregulation of redox pathways in liver fibrosis.Extracellular vesicles in liver pathobiology: Small particles with big impact.Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice.Intestinal microbiota and nonalcoholic steatohepatitis.Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases.Mitochondrial DNA in innate immune responses and inflammatory pathology.Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice.Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and ActivationCold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma.The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA.Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome.Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?Hepatocyte mitochondrial DNA released in microparticles and toll-like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis.RBCs Homeostatically Bind mtDNA Through TLR9 to Maintain Quiescence and Prevent Lung Injury.MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock.Chemotherapy-Induced Tissue Injury: An Insight into the Role of Extracellular Vesicles-Mediated Oxidative Stress Responses.Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation.Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis.Cell-free DNA is higher and more fragmented in intrahepatic cholestasis of pregnancy.The Effects of Physical Exercise on Fatty Liver Disease.Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation.Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy.Microparticle and mitochondrial release during extended storage of different types of platelet concentrates.Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice.Antiapoptotic BCL-2 proteins determine sorafenib/regorafenib resistance and BH3-mimetic efficacy in hepatocellular carcinoma.A leukocyte activation test identifies food items which induce release of DNA by innate immune peripheral blood leucocytes.Extracellular vesicles as potential biomarkers for alcohol- and drug-induced liver injury and their therapeutic applications.Deoxyribonuclease partially ameliorates thioacetamide-induced hepatorenal injury.Deficiency in plasmacytoid dendritic cells and type I interferon signalling prevents diet-induced obesity and insulin resistance in mice.Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress.NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection.The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies.New application of anti-TLR monoclonal antibodies: detection, inhibition and protection.Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA.Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases
P2860
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P2860
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
@ast
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
@en
type
label
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
@ast
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
@en
prefLabel
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
@ast
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
@en
P2093
P2860
P921
P356
P1476
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
@en
P2093
Albert Candia
Mark J Shlomchik
Rafaz Hoque
Robert Lee Coffman
Sonia Caprio
Wajahat Zafar Mehal
Xinshou Ouyang
Yonglin Chen
P2860
P304
P356
10.1172/JCI83885
P407
P577
2016-01-25T00:00:00Z