Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

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A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications.

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Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

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2016 nî lūn-bûn

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Dietary Dihydromethysticin Inc ...... y Enhancing Its Detoxification

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Dietary Dihydromethysticin Inc ...... y Enhancing Its Detoxification

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Dietary Dihydromethysticin Inc ...... y Enhancing Its Detoxification

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Dietary Dihydromethysticin Inc ...... y Enhancing Its Detoxification

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Dietary Dihydromethysticin Inc ...... y Enhancing Its Detoxification

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Chengguo Xing

http://www.w3.org/2001/XMLSchema#string

Jordan Paladino

http://www.w3.org/2001/XMLSchema#string

Linda B von Weymarn

http://www.w3.org/2001/XMLSchema#string

Pablo Leitzman

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Pramod Upadhyaya

http://www.w3.org/2001/XMLSchema#string

Sharon E Murphy

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Sreekanth C Narayanapillai

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Stephen S Hecht

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Steven G Carmella

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P2860

Cancer statistics, 2013

Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4

UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility.

Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats.

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco.

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.

CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6.

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422-427

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scholarly article

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10.1124/DMD.115.068387

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2016-01-07T00:00:00Z

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26744252

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4767383

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Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

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P2860

P2860

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

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