A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly.
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Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome EditingRegulation of zebrafish sleep and arousal states: current and prospective approachesTranscription activator-like effectors: a toolkit for synthetic biologyQuantifying on- and off-target genome editingTranscription activator-like effector nuclease (TALEN)-mediated CLYBL targeting enables enhanced transgene expression and one-step generation of dual reporter human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines.Mutagenesis and phenotyping resources in zebrafish for studying development and human diseaseThe position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotidesPrecise gene modification mediated by TALEN and single-stranded oligodeoxynucleotides in human cellsNorepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish.TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicityTargeted genome engineering techniques in Drosophila.Genome-Edited T Cell Therapies.Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.Methods for targeted mutagenesis in zebrafish using TALENsTranscription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing.Comprehensive analysis of the specificity of transcription activator-like effector nucleases.Strategies for gene disruption in DrosophilaGenomic editing tools to model human diseases with isogenic pluripotent stem cells.Damaging the Integrated HIV Proviral DNA with TALENs.Targeted genome engineering in human induced pluripotent stem cells by penetrating TALENs.High efficiency In Vivo genome engineering with a simplified 15-RVD GoldyTALEN designTargeted mutagenesis in the malaria mosquito using TALE nucleases.Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast.Exploring the transcription activator-like effectors scaffold versatility to expand the toolbox of designer nucleases.Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish.Feed your head: neurodevelopmental control of feeding and metabolismIn situ genetic correction of F8 intron 22 inversion in hemophilia A patient-specific iPSCsQRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish.Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.Targeted mutagenesis of Arabidopsis thaliana using engineered TAL effector nucleases.Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila.Rapid assembly of customized TALENs into multiple delivery systems.Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease.New model systems to illuminate thyroid organogenesis. Part I: an update on the zebrafish toolbox.New and TALENted genome engineering toolbox.The CRISPR system--keeping zebrafish gene targeting fresh.Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish.Engineering subtle targeted mutations into the mouse genome.Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of agingGenome engineering via TALENs and CRISPR/Cas9 systems: challenges and perspectives.
P2860
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P2860
A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
A large-scale in vivo analysis ...... ng context-dependent assembly.
@ast
A large-scale in vivo analysis ...... ng context-dependent assembly.
@en
type
label
A large-scale in vivo analysis ...... ng context-dependent assembly.
@ast
A large-scale in vivo analysis ...... ng context-dependent assembly.
@en
prefLabel
A large-scale in vivo analysis ...... ng context-dependent assembly.
@ast
A large-scale in vivo analysis ...... ng context-dependent assembly.
@en
P2093
P2860
P356
P1476
A large-scale in vivo analysis ...... ng context-dependent assembly.
@en
P2093
Brett J Niles
Cindy N Chiu
David A Prober
Grigorios Oikonomou
Igor Antoshechkin
Justin Liu
Shijia Chen
P2860
P304
P356
10.1093/NAR/GKS1356
P407
P50
P577
2013-01-08T00:00:00Z