Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials
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Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and SimulationsRecent developments in using mechanistic cardiac modelling for drug safety evaluationModeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety AssessmentChaste: an open source C++ library for computational physiology and biology.Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator.3D Finite Element Electrical Model of Larval Zebrafish ECG SignalsHuman-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.Images as drivers of progress in cardiac computational modelling.Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study.Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes.Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information.The effect of network biology on drug toxicology.Computational modeling of the obstructive lung diseases asthma and COPD.Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytesIn silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual levelEnsuring reliability of safety-critical clinical applications of computational cardiac models.Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein modelIn silico assessment of drug safety in human heart applied to late sodium current blockersAdvances in modeling ventricular arrhythmias: from mechanisms to the clinic.How computer simulations of the human heart can improve anti-arrhythmia therapy.Multiscale Modeling in the Clinic: Drug Design and DevelopmentRescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.Computational Models for Predictive Cardiac Ion Channel Pharmacology.Effects of L-type calcium channel and human ether-a-go-go related gene blockers on the electrical activity of the human heart: a simulation study.Replacing the thorough QT study: reflections of a baby in the bath water.Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block.Arrhythmogenic effect of androgens on the rat heart.Composite Biomarkers Derived from Micro-Electrode Array Measurements and Computer Simulations Improve the Classification of Drug-Induced Channel Block.Computational techniques for ECG analysis and interpretation in light of their contribution to medical advances.In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology.Validation and Trustworthiness of Multiscale Models of Cardiac Electrophysiology.Scalable and Accurate ECG Simulation for Reaction-Diffusion Models of the Human Heart.
P2860
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P2860
Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Computational assessment of dr ...... nel to body surface potentials
@ast
Computational assessment of dr ...... nel to body surface potentials
@en
type
label
Computational assessment of dr ...... nel to body surface potentials
@ast
Computational assessment of dr ...... nel to body surface potentials
@en
prefLabel
Computational assessment of dr ...... nel to body surface potentials
@ast
Computational assessment of dr ...... nel to body surface potentials
@en
P2093
P2860
P50
P1476
Computational assessment of dr ...... nel to body surface potentials
@en
P2093
Blanca Rodriguez
Miguel O Bernabeu
Pras Pathmanathan
P2860
P304
P356
10.1111/J.1476-5381.2012.02200.X
P407
P577
2013-02-01T00:00:00Z